11/25/2016

What is Dihydroquercetin (Taxifolin)?

Larch Root Extract

Botanical Name:Larix gmelinii (Rupr.) Rupr.
Chemical family: Bioflavonoids

Plant sources: Pinaceae plants like Larch, Douglas fir, Jinliu Branch plants like Lines of trees, Rosaceae plants like Wild black cherry, wood, Aralia grassroots, Lacertaceae plants like Pistacia chinesis Bunge, Labiatae plant like Anbo forskohli leaves.

Active Ingredient: Dihydroquercetin (Taxifolin) 90%-98%
Other Ingredients: aromadendrin, eriodictyol, quercetin, naringenin, pinocembrin

Physical properties: fine light yellow powder, soluble in ethanol, acetic acid, boiling water, slightly soluble in cold water, almost insoluble in benzene. The extract used to root.

Dihydroquercetin
CAS: 480-18-2
Molecular formula: C15H12O7
Molecular weight: 304.25
Others:taxifolin(2r,3r)-3,3',4',5,7-pentahydroxyflavanone;(2r,3r)-Dihydroquercetin                                              
 Dihydroquercetin, also known as Taxifolin or taxodium, belongs to vitamin p, is a kind of dihydro ketone alcohol compounds. First, it could affect the metabolism of fat by regulating the activity of enzymes, inhibiting in synthetic of liver fat; it is obviously inhibiting esterification of cholesterol in liver cancer cells and synthesis of triacylglycerol and phospholipids, effectively activate phosphodiesterase. Second, it is the role of larger lymphocytes can inhibit lymphocytic disease. The third can effectively inhibit the growth of squamous cell carcinoma and leukemia cells. The fourth with a significant antioxidant effect. The antioxidant power of dihydroquercetin is 3-5 times that of quercetin, which is widely used shows by researches. Fifth, reduce intestinal peristalsis, inhibition of aldose reductase, reduction of cytochrome c, mitochondrial oxidation of the respiratory chain inhibition, reduce blood lipids, protect the vessel wall, anti-inflammatory, the role of the protection of the stomach.
At present, the main application in three areas: First, the food industry, that is, food additives. Its antioxidant capacity, especially in the high-dose test did not find it on the fetus teratogenic, mutagenic, allergic effects, can be used for vegetable oil, animal fats, dry milk powder, fat candy heart children, can extend its validity 2-3 times, and improve food properties; Second, the pharmaceutical industry. Such as the treatment of the human circulatory system, that is, to enhance the flexibility of the vessel wall; such as the manufacture of radiation therapy, radiation effects of drugs, manufacture anti-aging drugs, treatment of genetic abnormalities and improve immune function drugs, Cells and cause cancer cells kill each other, and no effect on normal cells; anti-virus, anti-inflammatory significantly. At the same time can be used as pharmaceutical intermediates. Third, industrial. For the anti-seismic, stabilizer, paint antioxidants, rocket fuel, engine oil additives.

Dihydroquercetin as health food products mainly functions with:
1.Antioxidant properties: Dihydroquercetin will remove free radicals in the body, anti-oxidation, anti-aging.
2.Protection of capillary performance: Dihydrogenated quercetin can maintain cells, membranes and other human tissues and organs; consolidate blood vessels and capillaries, regulate blood lipids.
3. Anti-inflammatory properties: prevention and treatment of inflammation, prevent edema.
Protection of liver function: to prevent the virus and toxins on the liver damage.
4.Anti-allergy: the allergen removed from the human body and improve the body's resistance to allergens.
5.Radiation protection: to promote the rehabilitation of people after radiation.
6. Improve the reproductive capacity of performance: to improve male and female reproductive capacity, promote gonadal function, Bushen impotence.

Pharmacological activity:
1. Anti-cancer: the mouse leukemia P388 activity, 150 and 100mg / kg life extension rates were 40% and 37%.
2. Antibacterial: Staphylococcus aureus, Escherichia coli, Shigella and Salmonella typhi have a strong antibacterial effect

Application: Dihydric quercetin can be used as high-grade food raw materials, health products and pharmaceutical raw materials, can also be used in alcohol, to eliminate the adverse reactions after drinking.
(amy.cheng@cimasci.com)