General information:
Product name: Oleoylethanolamide, N-Oleoylethanolamide, OEA
Other names: N-(2-Hydroxyethyl)-9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, N-(2-Hydroxyethyl)oleamide, 9-Octadecenamide
CAS No: 111-58-0
EINECS:203-884-8
Assay: 85%, 90%
Molecular Formula: C20H39NO2
Molecular Weight:325.5
Test Method: GC
What is Oleoylethanolamide (OEA)?
Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.
Where it comes from:
Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a lipid that's synthesized naturally by the intestines.
The presence of Oleoylethanolamide (OEA) is higher during the day when the body is fully saturated with food and lower at nighttime during periods of starvation.
What it'll do for you:
"Studies report that OEA can turn off the switch in the central nervous system for hunger," explains Roberta Anding, RD, ADA spokesperson, and sports dietitian for the Houston Texans.
How does Oleoylethanolamide (OEA) work?
Before 2001, there wasn't much research on Oleoylethanolamide supplement or N-Oleoylethanolamide (OEA). But that year, Spanish researchers broke down the lipid and studied how it's made, where it's used and what it does. They tested the effect of OEA on the brain (of rats) by injecting it directly into the brain ventricles. They found no effect on eating and confirmed that OEA does not act in the brain, but rather, it triggers a separate signal that affects hunger and eating behavior.
Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) acts on a receptor called Peroxisome Proliferator-Activated Receptor Alpha (PPARĪ±). When this receptor is activated in the intestines of rats, the animals consume less food. Research on rats shows that both injections and oral intake of OEA cause a reliable reduction in the amount of food eaten.
How to take Oleoylethanolamide (OEA)?
Research on rats has observed effects at a daily dose of 10mg/kg of body weight. This is roughly equivalent to the following human dosages:
100mg for a 150lb person
145mg for a 200lb person
180mg for a 250lb person
Main Function of Oleoylethanolamide (OEA)
- Modulate food intake
- Modulate lipid and glucose metabolism
- The beneficial effect on analgesic
- Promote neurogenesis and neuroplasticity after focal cerebral ischemia
- Antidepressant
Application of Oleoylethanolamide (OEA)
Mainly mix with Green Tea extract, Green Coffee bean extract, phosphatidylcholine, and other ingredients. Used in Healthcare supplement, made into Hard capsule or tablet for Weight loss.
