Oleylethanolamide VS cannabinoid anandamide

The effects of OEA were first studied because it shares similarities with another chemical, a cannabinoid known as anandamide. Cannabinoids are related to the plant Cannabis, and anandamides present in the plant (and marijuana) can increase a person’s desire to snack by triggering a feeding response. According to Wikipedia, Oleoylethanolamide is the monounsaturated analog of the endocannabinoid anandamide. Although OEA has a chemical structure that is similar to anandamide, its effects on eating and weight management are different. Unlike anandamide, OEA acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis.

Structures of various fatty-acid ethanolamides: Oleoylethanolamide (OEA), palmitoylethanolamide (PEA) and anandamide (arachidonoylethanolamide, AEA). (Cima Science Co., Ltd is the only manufacturer of bulk raw materials of OEA, PEA, and AEA in China, if you need sample and price quote, please drop us an email with amy.cheng@cimasci.com)

OEA:

Make sure that our OEA is a raw material in powder form instead of capsules or tablets. Some companies use Oleoylethanolamide powder (standardized to 15% Oleoylethanolamide) or Oleoylethanolamide oleic acid 50% in their finished products. The specifications of Cima OEA is 90% min, up to 95%, quality is satisfied among our buyers in the United States and Europe.

PEA: palmitoylethanolamide (Cas no.544-31-0) powder, ultra micronized PEA powder

SVA: Stearoyl Vanillylamide (Cas no.58493-50-8) powder

Read more details at https://cimasci.com/products/oleoylethanolamide/

Safety of Nicotinamide Riboside(NR)

Safety of Nicotinamide Riboside(NR)

The two major forms of vitamin B3, nicotinic acid and nicotinamide, are together commonly known as niacin, and constitute the best well-known NAD+ precursors. Nicotinamide riboside (NR) is a single chemical moiety containing nicotinamide and ribose and, because it is a precursor of nicotinamide adenine dinucleotide (NAD+ ), is considered to be a form of vitamin B3 (reviewed in Chi and Sauve 2013; Penberthy and Kirkland, 2012; Bogan and Brenner, 2008). 

Intake of nicotinic acid at doses of 50 mg/day and higher consistently results in undesirable side effects, including vasodilation effects (flushing) and pruritus (itching), which can occur within 30 minutes following oral administration (Guyton and Bays, 2007), whereas NR and nicotinamide are not associated with these adverse effects. NR may not cause flushing because just like nicotinamide, it does not bind GPR 109a, the high-affinity G-protein coupled receptor that is believed to play an important role in mediating the vasodilatory effects of nicotinic acid (Canto et al. 2012).                                                                            

--GRAS-NR-ChromaDex

Nicotinamide riboside chloride Price

Nicotinamide riboside chloride

CAS NO.:23111-00-4

Synonyms:Nicotinamide riboside chloride;3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride;3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride;3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium chloride;Nicotinamide B-D Riboside Chloride(WX900111);Nicotinamide Riboside.Cl 

Chemical Name:3-(amiocarbonyl)-1-β-D-ribofuranosyl-pyridinium cloride (1:1)

Molecular Formula:C11H15N2O5.Cl

Molecular Weight:290.7
Reference price:usd1300-usd1500/kg

Benefits of Nicotinamide riboside chloride

Delay aging

Improve cardiovascular health

Improve brain health

Improve fat metabolism

Improve the body's resistance to cancer cells

Detoxification

Beauty effect

Similar products:

NMN:(β-Nicotinamide Mononucleotide, CAS NO.1094-61-7),purity >98%

NR:(Nicotinamide Riboside Chloride,CAS NO.23111-00-4),purity >97%

NAD+:(β-NAD+,food grade,CAS NO.53-84-9),purity >98%

NADH:(β-Nicotinamide Adenine Dinucleotide, CAS NO. 606-68-8) 

Nicotinamide adenine dinucleotide phosphate: oxidized (NADP+) and reduced (NADPH) 

Nicotinamide riboside (NR) 1-(β-D-Ribofuranosyl)nicotinamide N-Ribosylnicotinamide CAS 1341-23-7

Nicotinamide riboside (NR) is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

Chemical information:
Nicotinamide riboside (NR)
Other names: 1-(β-D-Ribofuranosyl)nicotinamide; N-Ribosylnicotinamide
CAS Number:1341-23-7

MF: C₁₁H₁₆N₂O₅

MW:256.26

Cimasci. offer Nicotinamide riboside (NR) with stocks, fine powder 

Similar products:

NMN:(β-Nicotinamide Mononucleotide, CAS NO.1094-61-7),purity >98%

NR:(Nicotinamide Riboside Chloride,CAS NO.23111-00-4),purity >97%

NAD+:(β-NAD+,food grade,CAS NO.53-84-9),purity >98%

NADH:(β-Nicotinamide Adenine Dinucleotide, CAS NO. 606-68-8) 

Nicotinamide adenine dinucleotide phosphate：oxidized (NADP+) and reduced (NADPH)

What is alliin?

Alliin 98%

Synonyms: (2R)-2-amino-3-[(S)-prop-2-enylsulfinyl]propanoic acid, 3-(2-Propenylsulfinyl)alanine, (S)-3-(2-Propenylsulfinyl)-L-alanine, 3-((S)-Allylsulfinyl)-L-alanine, S-Allyl-L-cysteine sulfoxide, SACS, S-allyl cysteine sulfoxide, New-Gar®, allicin precursor, S-allyl cysteine sulphoxide
Botanical source: Allium sativum L.
Part Used: Garlic Bulb
CAS Number: 556-27-4
Molecular Formula: C₆H₁₁NO₃S

Specification: 98% min
Standard: Enterprise Standard
Appearance: White to yellowish powder
Solubility: Soluble in water
Benefits: cardiovascular health, Maintains healthy cholesterol, anti-inflammatory, Myocardial infarction,
Applications: Food additives, supplements, drugs, medicines
Dosage: Vary upon different applications

Wuxi Cima Science Co., Ltd is a professional manufacturer of nutritional raw ingredients specializing in garlic active ingredient series products, such as alliin, allicin, ajoene, etc. Commercial production and the ready stock is available.

More details please check https://cimasci.com/products/alliin-98/

Polydatin Price

Polydatin

Plant description

1. Plant source: The rhizome of the Polygonum cuspidatum Sieb. et Zucc.

2, origin: distributed in central and southern China, produced in Hunan, Hubei, Jiangsu, Zhejiang, Jiangxi, Fujian, Henan, Shaanxi, Sichuan, and other places. Born in the valley, by the river or on the shore.

Product description

CAS No.: 27208-80-6

English name: Polydatin, Piceid

Chemical name: 3-Hydroxy-5-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl-beta-D-glucopyranoside

Composition Category: Stilbene steroids

Traits: white powder (98%)

Specification: 98% (HPLC)

Polydatin Price:usd400-usd475/kg

Molecular weight: 390.38

Molecular formula: C₂₀H₂₂O₈

Structure:

Pharmacological effects:

(1) hypolipidemic and anti-lipid peroxidation

Studies have found that sublingual Polydatin 2.2mg.kg / d for 3 consecutive days, can increase the elevated serum cholesterol, low-density lipoprotein /high-density lipoprotein (LDL / HDL) ratio and hematocrit to normal, It also has a tendency to reduce the high shear rate and the low shear rate of whole blood. Another study has determined the degree of lipid peroxidation under the influence of exogenous free radicals and found that Polydatin can improve the stability of lipid membranes and has significant resistance. Lipid Peroxidation.

(2) Effects on vascular smooth muscle cells

The effect of Polydatin on rat vascular smooth muscle cells and human umbilical cord arterial smooth muscle cells showed that Polydatin has a two-way regulation of intracellular calcium pH. Under normal conditions, Polydatin not only promotes vascular smooth muscle extracellular calcium ions into cells but also induces cells. Intracellular calcium release, increase intracellular free calcium, increase PH to increase vascular tone, reduce intracellular calcium concentration during shock and reduce intracellular pH to reduce vascular tone, dilate blood vessels, and promote extracellular sodium ion inflow Cells are depolarized to regulate blood vessels, which may be involved in the opening of sodium and potassium channels and are inversely regulated by the adrenergic receptor H2 receptor system and the guanylate cyclase system.

(3) The effect on cardiomyocytes

It has been reported that studies on rat cardiomyocytes indicate that the cardiotonic effect may directly enhance myocardial contractility by increasing the concentration of free calcium ions in individual cells. This effect of Polydatin makes it theoretically superior to the digitalis of the digitalis, which not only makes the myocardial contraction more powerful but also makes the myocardial relaxation more thorough, thus greatly improving myocardial work efficiency.

(4) Hang platelet aggregation and improvement of microcirculation

Studies have found that Polydatin inhibits arachidonic acid, adenosine diphosphate, and adrenaline-induced rabbit platelet aggregation in vitro and in vivo, which is stronger than aspirin, indicating that anti-thrombosis of Polydatin is closely related to stronger anti-platelet aggregation. Related. This has a certain application value for the prevention and treatment of thromboembolic diseases.

(5) Antioxidant and liver protection

Oxygen free radical production is an important mechanism for causing multiple organ failure. Polydatin has significant antioxidant protection against the liver and inhibits the accumulation of lipid peroxides in the liver. Studies have shown that Polydatin can significantly inhibit the oxidative damage of mouse hepatocytes induced by hydrogen peroxide in a certain concentration range, and can improve superoxide dismutase (SOD) and glutathione peroxidation in hepatocytes. (GSH-Px) activity, reduce GSH consumption, reduce malondialdehyde (MDA) content, inhibit nitric oxide synthase (NOS) activity, reduce nitric oxide (NO) production and oxidation, thereby reducing oxide pairs Damage to liver cells.

Applications: In recent years, there have been more and more pharmacological and applied researches on polydatin. Polydatin and its products are widely used in medicine, beauty, health care, food, and other fields.

Recommended dosage:

Dietary supplements: As a food supplement for the antioxidant and health-promoting cardiovascular system, the recommended dose is 50-100 mg per day based on the active ingredient polydatin.

Wuxi Cimasci. could offer Polydatin 98%powder in stocks and formula matching with Palmitoylethanolamide (PEA), welcome your kind inquiry!

N-Methyl-D-aspartic acid(NMDA) Price

N-Methyl-D-aspartic acid or N-Methyl-D-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors. NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.

English name: N-Methyl-D-aspartic acid

CAS: 6384-92-5

English alias:(R) -2- (Methylamino) succinic acid; NMDA; (2R) -2- (methylammonio)               butanedioate

Chemical names: N-methyl-D-aspartic acid;NMDA; 6384-92-5; N-Methyl-D-aspartate; N-Methylaspartate; N methyl D aspartate;

Molecular formula: C5H8NO4

MW: 146.1219

Specification:  ≥98%

Melting point: 187-192 ℃

Solubility: slightly soluble

Package:1kg/bag,25kg/drum

Brand name:Cimasci

Package:1kg/drum,25kg/drum

N-Methyl-D-aspartic acid(NMDA) Price: is usd490-usd550/kg

Magnesium L-Threonate Price

Magnesium L-Threonate

CAS Number: 778571-57-6
FM: C₈H₁₄MgO₁₀

Specification: 95.0% ~ 102.0% (Titration)
Magnesium L-Threonate Price: is usd50-usd70/kg

Appearance: A white or almost white crystalline powder, odorless, practically tasteless
Solubility: Insoluble in methanol, and soluble in water freely
Synonyms: MgT, Magnesium bis [(2R, 3S) -2,3,4-trihydroxybenzoic]
Categories: Longevity, Nootropic
Package: 1kg / bag, 25kg / drum
Delivery time: 3-5 days

Thymoquinone Price

Nigella sativa extract- Thymoquinone

Botanic Name: Nigella damascena

Appearance: Yellowish orange to dark orange powder

Specification: 5%  Thymoquinone price is usd100-usd150/kg

                       10% Thymoquinone price is usd160-usd240/kg

Test Method: HPLC

Packaging: 25kg / drum

Shelf life: 2 years

Thymoquinone is a phytochemical compound found in the plant Nigella sativa.

It has antioxidant effects and has been shown to protect against heart, liver and kidney damage in animal studies as well as having possible anti-cancer effects. 

It also has analgesic and anticonvulsant effects in animal models. It is an angiogenesis inhibitor.

In 2008 in-vitro tests showed it was an HDAC inhibitor, affecting genes such p53, Bax, bcl-2 and p21.  

Thymoquinone has been studied for its potential effects on colon cancer cells. It reduces mouse colon tumor cell invasion and inhibits tumor growth in animal models of colon cancer. The stress response sensor CHEK1 may contribute to the anti-colon cancer effects of thymoquinone. Thymoquinone may affect immune function by influencing dendritic cell functions such as maturation, cell pH (by affecting Na + / H + activity), oxidative burst, migration and cytokine release. Dendritic cell volume may also be affected by thymoquinone.

Thymoquinone has been shown to induce apoptosis in thrombocytes, an effect largely dependent on PI3K signaling. In colorectal cancer, however, thymoquinone's apoptotic effects arise from inhibition of the MEK1 / 2 pathway instead of PI3K. In this case, cell-specific apoptosis in tumors is induced through the former pathway. This is associated with a reduction in GSK-3β phosphorylation (increased activation) and subsequent translocation of β-catenin to the cellular membrane where the stabilized protein would fail to induce proliferation. It is reported that in a mouse model of breast cancer model and in cancer cell lines in vitro, thymoquinone downregulates TWIST1 transcription factor to reduce epithelial to mesenchymal transition and thus inhibits metastasis.

Pterostilbene 99%Price

Pterostilbene 

Pterostilbene is white or almost white crystalline powder, dragon's blood products is an antifungal active ingredient, is a multi stilbene compounds, homologues of resveratrol and resveratrol in addition to its pharmacological effects similar to some but also has strong antifungal activity (antifungal activity of resveratrol five times) for cancer, hypertension, high cholesterol have a certain therapeutic effect.

Cas No.:537-42-8

Molecular Formula: C₁₆H₁₆O₃

Molecular Weight: 256.30

Purity: ≥99%

Other name: Trans-pterostilbene

3,5-Dimethoxy-4'-hydroxystilbene;4-[(1E)-2-(3,5

Dimethoxyphenyl)ethenyl]phenol, Pterocarpus marsupium

Appearance:White crystalline powder

Package:500g/bag,1kg/bag,25kg/drum

Application: for anti-oxidation, anti-cell proliferation, blood fat, lowering blood pressure

Pyrroloquinoline quinone(PQQ)

Pyrroloquinoline quinone

Pyrroloquinoline quinone (Pyrroloquinoline quinone, abbreviated as PQQ) by bacteria present in the relay outside nicotinamide and flavin third redox cofactors J · G · Haug (JG Hauge) found (although it is assumed that they had naphthoquinone). Anthony also found in alcohol dehydrogenase this unknown redox cofactor and name it "methoxatin". In 1979, PQQ or PQQ was first discovered, is considered a new B vitamin.

Chinese name: pyrroloquinoline quinone

English name: Pyrroloquinoline quinone

CAS NO.:122628-50-6

Molecular formula: C14H6N2O8

Molecular Weight: 374.17

Appearance: reddish brown powder

Specifications: 98% Min

The main function:

Anti-Aging

Neuroprotection

Increased mitochondrial density

Reduce inflammation

Promote metabolism

Powerful antioxidant properties

Improve learning and memory

Oleoylethanolamide (OEA) Function

Oleoylethanolamide (OEA)

CAS #: 111-58-0
EINECS： 203-884-8
Molecular Weight: 325.53
Molecular Formula: C₂₀H₃₉NO₂

Other Names:
N-(2-Hydroxyethyl)-9-octadecenamide,9-octadecenamide, N-Oleoylethanolamine
Solubility: chloroform, ethanol, methanol, ethyl ether, DMSO
Manufacturer: Cima
Package:1kg/bag, 25kg/drum

Introduction
CimaSci promotes health and well-being through the discovery and development of nutraceutical ingredient which can be integrated into dietary splements, nutritional production, and medicine.

Oleoylethanolamide (OEA) is an endocannabinoid analog thaupt belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.

Function:
ü Modulate food intake
ü Modulate lipid and glucose metabolism
ü Beneficial effect on analgesic
ü Promote neurogenesis and neuroplasticity after focal cerebral ischemia
ü Antidepressant

Alpha-GPC Dosage

Alpha-GPC Introduction

L-Alpha Glycerylphosphorylcholine (also known as Alpha-GPC, choline alfoscerate) is a key brain cell membrane phospholipid and cholinergic precursor. It is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources. Alpha-GPC may have a potential for the treatment of Alzheimer's disease and is used as a nootropic dietary supplement to enhance memory and cognition.

Research suggests this supplement counters amnesia and resets memory for some users, making it an aid for those suffering from Alzheimer’s disease, senility and other brain disorders where mental focus is lost. Often, those without mental problems, including children, take it for alertness and fast response to stimuli. Male and female users often report a return of sexual interest and stamina after taking this compound. Liver disorders can also reportedly be corrected by the supplement.

In Europe, alpha-GPC is a prescription medication for the treatment of Alzheimer's disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.

Profile of Alpha-GPC

Cas No.: 28319-77-9       

Molecular Weight: 257.221

Molecular Formula: C₈H₂₀NO₆P

Other Names: Choline Alfoscerate

        Choline  alfoscerate

         L-Alpha Glycerylphosphorylcholine

         2,3-Dihydroxypropyl 2-trimethylazaniumylethyl phosph

How does Alpha-GPC work?

Alpha-GPC seems to increase a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions.

Alzheimer's disease. Developing research suggests that taking 1200 mg of alpha-GPC per day significantly improves thinking skills in Alzheimer's patients after 3 to 6 months of treatment.

Dementia. Giving 1000 mg of alpha-GPC per day as a shot might improve symptoms of vascular (multi-infarct) dementia including behavior, mood, and thinking skills. Researchers who did this study used a prescription-only form of alpha-GPC (Deficit) that is not available in the US.

Stroke and “mini-stroke” (transient ischemic attack, TIA). Stroke and TIA patients who receive alpha-GPC within 10 days after the stroke or TIA seem to have a better recovery. Early research suggests that people who get 1200 mg of alpha-GPC per day as a shot for 28 days, followed by 400 mg of alpha-GPC three times daily (1200 mg/day) by mouth for 6 months, recover more thinking skills and are better able to function.

Improving memory.

Thinking skills.
Learning.

(amy.cheng@cimasci.com)

http://www.cimasci.com/
http://www.cimascience.com/

PEA Micronized powder Price

Palmitoylethanolamide

English name: Palmitoylethanolamide

Alias Name: N- (2-Hydroxyethyl) hexadecanamide

More Alias: Palmidrol

CAS NO:. 544-31-0

Category: Synthesis

Molecular formula: C18H37NO2

Molecular Weight: 299.5

Appearance: white crystalline solid

Storage temperature: -20 ℃

Specifications:

PEA 98%powder; Price is usd110-usd125/kg

PEA Micronized powder; Price is usd120-usd135/kg

PEA capsules(400mg).

Detection methods: gas chromatography (GC)

Function: anti-inflammatory, to relieve pain