2/14/2019

What is CimaPQQ?


Introduction of CimaPQQ

(amy.cheng@cimasci.com)

1. What is PQQ?
Pyrroloquinoline quinone (PQQ), also known as methaxatin, is a new prosthetic group after flavin nucleotide and nicotinamide nucleotide, found in bacterial membrane-bound dehydrogenase; was called fourteenth vitamins by World medical profession.PQQ in the powerful antioxidant, promote mitochondrial health, play an important role in the treatment of unparalleled neurodegenerative diseases. Traces of PQQ can improve metabolism and growth and function of living tissue, so it is extremely valuable.

2. Where could find PQQ?
In 1979, American scientists first identified the mysterious coenzyme is a three acid quinone compound, and name PQQ (PQQ) by using X-ray crystallography.
Today, scientists found that PQQ is not only present in some bacteria or bacteria-derived, also in a variety of plants, but animals and humans were also found to contain a trace amount of PQQ, such as parsley, green pepper, spinach, papaya, carrots, cabbage, natto, green tea, and tofu. Because some bacteria synthesize PQQ was minimal, simply can not meet the body's needs. Therefore, animals and humans can only be obtained from PQQ supplements.

3. What functions of PQQ?
1) PQQ is considered a powerful antioxidant
PQQ is considered the superior oxidation resistance of biologically active substances and always been of concern by nutritionists for its unique physical and chemical properties and a variety of physiological functions. Cells, tissues, and organs of the oxidation-reduction balance damage, leading to the tissue and organ function disorder, decreased immunity. Studies have shown that PQQ is essential to the human body a vitamin-like coenzyme factor. Because it has remarkable stability of the molecule, can promote cell regeneration and body growth. It is comparable to phase antioxidant resveratrol, quercetin, green tea extract, and even stronger effect.

2)PQQ promotes mitochondrial health, an essential nutrient
Enhancement of mitochondrial function. Mitochondria are known as “powerhouses” of the cell and are responsible for fueling the cell with energy. In everyday life, it can help us to generate 90% of the energy for normal human breathing, thinking and operating, and we have the heart and brain mitochondria with high energy demand.PQQ appears to enhance mitochondrial function in both laboratory animals and humans, which helps cells, including our neurons, maintain the energy to function at peak performance.

3)PQQ can help prevent dangerous neurodegeneration
Neurodegeneration is the process by which our brain cells, or neurons, become damaged, lose function, and even die. Neuronal damage will gradually lead to cognitive decline, and thus the occurrence of Alzheimer's disease and neurodegenerative diseases.PQQ can repair nerve fibers, activation of neurons, nerve cells activate dormant stimulate nerve growth factor, helps brain cells survive and maintain healthy brain function.

Also, PQQ has other functions,anti-aging, prevent and treat liver damage, protect the heart, adjust the balance of bone metabolism, prevent cataracts, improve sleep, anti-cancer, etc.

4.About CimaPQQ
1)What is CimaPQQ?
PQQ, a gold product of Cima, was popular at home and abroad. We manufactured it by the domestic top technical process with two main forms: Pyrroloquinoline Quinone Disodium Salt and Pyrroloquinoline Quinone acid.
Product Name
PQQ Acid
PQQ Disodium Salt
CAS No.
72909-34-3
122628-50-6
Molecular Weight
330.21
374.17
Molecular Formula
C14H6N2O8
C14H4N2Na2O8
Purity
99% Min
99%  
Appearance
Reddish Brown Powder
Reddish Brown Powder
Biggest differences: the higher price of the former than the latter; the latter is more stable and has a strong water-soluble and absorbency.

2)Why buy CimaPQQ?
In manufacturing:Cima invested in factory to product,and the average annual is 450kg,sure keep a long-term stable supply
In product:CimaPQQ with a moderate price, and purity reaches 99% test by a third party.
In Services:with leading technology and years of research experience, CIMA can provide customers with technical support and OEM services.

3)CimaPQQ typical nutritional combination
PQQ & CO-Q10
10 mg and 200 mg of coenzyme Q10 PQQ is combined with the current popular classic recipe, can significantly improve cognitive function, promote renewal and neuroprotective effect mitochondria.

PQQ & Alpha GPC
Alpha GPC is a pro-phospholipid that delivers the essential nutrient choline to the brain.A meta-analysis of 10 clinical trials evaluating Alpha GPC and PQQ,promote neurological health and support improved memory retention and mental acuity. A benefit that may be further enhanced with a daily regimen that also includes CO-Q10.

PQQ & Strontium citrate
Strontium citrate is a new nutritional supplement, mainly to promote bone structure, reduce osteoporosis.In combination with PQQ and Strontium citrate perfectly could regulate balance of bone metabolism,establish normal bone density, and absorb safely.

4)Dosage and side effects
In theory, benefits can be seen from supplementing PQQ as low as 1-2 milligrams per day.  However, most of the studies above used 10-30mg per day. To stay on the logical side of things, its best to use at least a 10mg dosage.
Side effects for PQQ are virtually nonexistent, besides mild transient headaches in a select few people.

5)Where to buy?
Wuxi Cima Science Co,.Ltd(www.cimasci.com)


What is Strontium Citrate ?


Strontium Citrate
strong your bone and health

Strontium Citrate
What Is It?

•Strontium is a trace element found in seawater and soil. The main dietary source of strontium is seafood. Foods with lesser amounts of strontium include whole milk, wheat bran, meat, poultry, and root vegetables.

•Strontium is chemically similar to calcium. It appears to play a role in the formation of new bone while slowing the breakdown of old bone, and thus may influence bone density. There is some evidence that women with osteoporosis may not absorb strontium as they should.

Chemical Profile

•CAS#: 813-97-8 
•Molecular Weight: 640.86
•Molecular Formula: (C6H5O7)2Sr3
•Other Names: Strontium 2-hydroxy-1,2,3-propanetricarboxylate; Tristrontium dicitrate

Strontium Increases Bone Mass Density

Strontium supplementation has been demonstrated to be a well-tolerated and effective means of preventing bone loss. In 2004, a double-blinded, placebo-controlled study published in The New England Journal of Medicine aimed to evaluate the efficacy of strontium on helping to prevent structural damage and bone fragility. Over a three- year period, strontium supplementation reduced the risk of fracture by 41%. This reduction in risk was closely tied to the increase in bone mineral density in the lumbar spine and femoral neck (Fig 1). The occurrence of adverse side effects was low and reported equally among the treatment and placebo groups, further indicating the safe use of daily strontium supplements.

Absorption
Bone Quality
Long-Term Effects

Safety & Precautions
When taken in recommended doses, strontium supplements appear to be safe. Aside from occasional mild gastrointestinal upset, includingdiarrhea, side effects are rare. However, excessive doses of strontium may replace too much calcium in the bone and hurt vitamin D metabolism, causing them to weaken.

WARNING: Do not take this product if you have a renal disorder or if you are pregnant or nursing. Do not exceed recommended dosage.

Supplying ingredients:www.cimasci.com 
Contact email:amy.cheng@cimasci.com

Pyrroloquinoline Quinone Disodium Salt (PQQ) Price

Pyrroloquinoline Quinone Disodium Salt

Cas No.:122628-50-6
Molecular Formula: C14H4N2Na2O8
Molecular Weight: 374.17
Specification: 98%
Appearance: Reddish Brown Powder
Reference price:usd2550-usd2950/kg

Introduction: Pyrroloquinoline quinone Disodium Salt is a new prosthetic group, as a novel water-soluble vitamin, it is rare and exists in a number of microorganism, plant and animal tissues, not only involved in the catalytic-vivo redox reaction but also has some special biological activity and physiological functions. Trace amounts of PQQ will be able to improve the living tissue metabolism and growth performance, extremely valuable.
Functions:
1. To improve the body's immunity
2. Prevention and treatment of liver injury
3. Reduce free radical damage to the human body
4. Regulate various neurological diseases
5. Promote the absorption of amino acids
6. The prevention and treatment of Alzheimer's disease
7. Active NK cell and strong anti-cancer activity
Application: Widely used for dietary supplement and nutraceuticals.
Storage: Stored in a cool and dry condition, away from direct sunlight.



Huperzine A Price


Huperzine A

Huperzine A is an active alkaloid extracted from Huperzia Serrata (Thunb.) Trev.


Chemical Profile
CAS No.: 102518-79-6
Molecular Formula: C15H18N2O
Specification:1~99% Yellow-brown Powder
Test Method: HPLC 
















Benefits
  • Enhance cognition, improve memory
  • Treat Myasthenia gravis
  • Treat age-related memory loss and Alzheimer disease 



Palmitoylethanolamide(PEA)Price

PalmitoylethanolamidePEA

Cas No.:544-31-0
Molecular Formula: C18H37NO2
Molecular Weight:299.5
Specification:98%
Appearance: Fine White Powder
Introduction: It is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA is one of the most important endogenous painkilling and anti-inflammatory compounds and has been shown effective for both acute and chronic pain. Because the substance acts as a natural painkiller, it is an excellent alternative for conventional medications that might cause side effects.
Functions:
1. Anti-Inflammatory and Analgesic
2. Improve immunity
3. Healthcare for chronic pain
4. Healthcare for epilepsy, cerebral ischemia, and stroke
Application: Used as a dietary supplement.
Storage: Stored in a cool and dry condition, away from moisture and direct sunlight.


99% SALIDROSIDE CAS 10338-51-9

Salidroside

Cas No.: 10338-51-9
Molecular Formula: C14H20O7
Molecular Weight: 300.304
Specification: 99%
Appearance: Fine White Powder
Introduction: Salidroside is a glucoside of tyrosol found in the plant Rhodiola Rosea. It is one of the compounds responsible for the antidepressant and anxiolytic actions of this plant. Salidroside 99% is synthesized by a kind of enzyme method technology that has the advantages of higher selectivity, higher product purity, easy to separation and purification.
Functions:
1. Protect Angiography; Resistance to altitude sickness
2. Scavenging free radical
3. Suppressing tumor growth
4. Skin whitening; Radioresistance
5. Antifatigue
6.Anti-aging; Scavenging free radical
Application: Used as a dietary supplement
Storage: Stored in a cool and dry condition, away from moisture and direct sunlight.


HYDROXYTYROSOL OLEUROPEIN NATURAL OLIVE EXTRACT

Olive Extract

Botanic NameOlea Europaea L.
Specification: Oleuropein 10% ~40%
            Hydroxytyrosol 1% ~98%
Appearance: Fine yellow-brown powder  
Introduction: Olive leaf extract has a broad-spectrum antimicrobial effect, containing many kinds of effective ingredients such as oleuropein, hydroxytyrosol, etc.
Functions:
1. Broad spectrum antimicrobial effect
2. Against cardiovascular disease
3. Improve immunity
Application: Used in medicine, dietary supplement, and cosmetics.
Storage: Stored in a cool and dry condition, away from moisture and direct sunlight.


Oleoylethanolamide(OEA)Price

OleoylethanolamideOEA

Cas No.: 111-58-0
Molecular Formula: C20H39NO2
Molecular Weight:325.5
Specification:85%-90%
Appearance: Fine White Powder
Introduction: Oleoylethanolamide(OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety following meals. Some evidence suggests that OEA may be able to aid fat loss by acting on PPAR. When this receptor is activated in fat tissue, energy expenditure increases.
Reference price:usd200-usd230/kg

Functions:
1. Suppresses food intake, weight loss management;
2. Lower blood fat and liver protection
3. Ischemic brain damage protection
Application: Used as a dietary supplement
Storage: Stored in a cool and dry condition, away from moisture and direct sunlight.


98%Thymoquinone(CAS 490-91-5)

Nigella Sativa Seed Extract 

Botanic Name: Nigella Sativa L.
Specification: 0.5~10%Thymoquinone
Appearance: Yellowish brown powder or clear yellow oil
Introduction: Nigella sativa is one magical traditional herb with a long history, Nigella sativa seed extract as one of the most amazing and unique herbal extract with multiple healthcare functions such as anti-cancer, lower blood pressure, etc,
Functions:
1. Anti-cancer and Anti-tumor effect
2. Anti-inflammatory and improve immunity
3. Diabetes healthcare
Applications: Used for the dietary supplement.
Storage: Stored in a cool and dry condition, away from direct sunlight.


Mulberry Leaf Extract 1-Deoxynojirimycin (1-DNJ) Price

Mulberry Leaf Extract

Botanic Name: Morus alba L.
Specification:1%~10% 1-Deoxynojirimycin (1-DNJ)
Appearance: Fine yellowish brown powder
Brief Introduction: Mulberry leaf extract, naturally obtained from the dry leaf of  
Morus alba L. through refining, concentration, and drying, is natural herbal extract.

Function:
1. Effectively lower blood sugar content, prevent diabetes
2. Inhibit the absorption of sugar by the small intestine, get the result of weight loss
3. Anti-bacterial, anti-inflammatory and anti-tumor
Application: Nutrition supplements, medicine, and cosmetics.
Storage: Stored in a cool and dry condition, away from moisture and direct sunlight