1/30/2019

Palmitoylethanolamide Price

(amy.cheng@cimasci.com)

What is Palmitoylethanolamide?

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists.PEA has been demonstrated to bind to a receptor in the cell nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. 



General information of Palmitoylethanolamide 

Palmitoylethanolamide
CAS No. 544-31-0
Molecular Weight: 299.5
Molecular Formula: C18H37NO2
Other Names: Hydroxyethyl Palmitamide
N-Palmitoylethanolamine
Palmidrol
Molecular Structural Formula:


What functions Palmitoylethanolamide have?

Anti-Inflammatory and Analgesic
Improve immunity
Chronic pain reduction
Epilepsy, cerebral ischemia, and stroke healthcare

How safe is Palmitoylethanolamide?

(1)PEA is a natural substance identical to the body’s own.
(2)In scientific literature, PEA is described as a very promising substance for various disorders that are accompanied by inflammations and infections.
(3)PEA (N-Palmitoylethanolamine) can be found in food, such as meat, eggs, soybeans, and peanuts.
(4)PEA can be used in combination with medication, antibiotics, anti-fever and anti-coughing medication, analgesics and/or anti-inflammatory agents.
(5)There are no known problematic side-effects of PEA (Palmitoylethanolamide 544-31-0).     
Regularly there are two forms: Palmitoylethanolamide powder and Ultra-micronized palmitoylethanolamide powder, the micronized palmitoylethanolamide is much easier to absorb than a common one. As one dietary supplement sold on the market, palmitoylethanolamide supplement is usually made into capsule and softgel form.


What are our advantages of Palmitoylethanolamide?

(1) Most professional and biggest PEA manufacturer in China
(2) Full series of specifications for your choice, including common palmitoylethanolamide (PEA) powder, ultra micronized PEA powder, micronized PEA granular
(3) High-quality palmitoylethanolamide produce under GMP facility
(4) Regular PEA stock available to guarantee one steady supply
(5) Stock in China and America warehouse to bring convenience to customers’ convenience from different areas
(6) Strong technical support for PEA, can offer customer one-stop solutions

FAQ

(1) Where can i find product detailes of your PEA ?
You can browse our website www.cimasci.com or www.cimascience.com to search palmitoylethanolamide or wuxi cima science co.,ltd to find the detailes.

(2) How can i buy your PEA ?
It is easy, you can send inquiry to our email amy.cheng@cimaci.com then our sales will contact at once, and lead you to operate step by step.

(3)What is the dosage of PEA ?
Usually final PEA product form is 400mg/capsule, according to pain level, the daily dosage could be from 400mg~2400mg

(4)What are your MOQ and Price?
We are the real manufacturer in China, can offer any amount you want, no MOQ limit.
Reference price:usd80-usd120/kg according to different quantities.

(5) What service you offer?
As one reputed company with years’ experience, we not only offer high quality palmitoylethanolamide, but also offer strong technical support as well as individual solutions for different customers. 

5, 7-Dimethoxyflavone 2.5%(Black Ginger)




Product name: Black Ginger Extract
Botanic Name: Kaempferia Parviflora
Active Ingredient: 5,7-Dimethoxyflavone
Specifications: 5,7-Dimethoxyflavone 2.5%
Appearance: Purple find powder



Benefits:
  1- Enhance energy and sexual function
  2- Boost metabolism
  3- Antianaphylaxis
  4- Regulate menopausal symptoms
  5- Regulate blood pressure
  6- Regulate liver function
  7- Anti-aging
  8- Accelerate blood circulation
  9- Regulating gastrointestinal health
  10- Anti-cancer




Vitexin 98% (HPLC)

Vitexin is an active flavonoid which can be found in many natural plants including passion flower, hawthorn, bamboo leaves, mung beans, pearl millet and fenugreek. Vitexin has a wide range of pharmacological effects, including but not limited to anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic and neuroprotective effects. Vitexin and its isomer isovitexin could be potential substitute medicines for diversity diseases.

Recently Wuxi Cima science co., Ltd, one experienced biological company in China, has isolated and commercialized high purity 98% vitexin from a natural herb, which can be used for the pharmaceutical field. Additionally, cima also can offer other specifications below 98% such as 10%, 20%, etc, as well as vitexin +isovitexin compound specification. The low specifications are much suitable for dietary supplements.
                                                                                                                            --From WUXI cimasci.

General information

Name: Vitexin
CAS NO.:3681-93-4
Other names: Apigenin8-C-glucoside
Chemical name: 8-β-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Molecular formula: C21H20O10
Molecular weight:432.3775
Purity:≥98% (HPLC)




















Functions of Vitexin
  • Have powerful antioxidant properties
  • Protection from Viral and Bacterial Invaders
  • Inhibit inflammatory pain
  • Anticancer
  • Diabetes
  • Heart Health
  • Anti-aging and Cognition


Palmitoylethanolamide Particle Size

Palmitoylethanolamide(Micronized PEA)
Cas No.:544-31-0

Cimascience.com offer Palmitoylethanolamide(Micronized PEA) with 97%min fine white powder,its particle size meet D(0.5):3μm ;D(0.9):10μm by Malvern Master Sizer(MMS).

So how to test its Particle Size rightly? 

Dispersant agent:Water

1. Adding small sample
2. the value of Refractive ratio is about 35% should be suitable as experience
3. Ultrasonic dispersion time is about 20 seconds

















amy.cheng@cimasci.com




Stearoyl Vanillylamide Price

General Information

Product name: Stearoyl Vanillylamide (SVA)
CAS number :58493-50-8
Molecular Formula: C26H45NO3
Molecular Weight: 419.64
Specifications: 98.0% -102.0% 
Appearance/Color : White to off-white powder
Functions: weight loss / fat burning
Manufacturer: Wuxi Cima Science co.,ltd
Package:1kg/BAG
Delivery time:3-5days
Reference price:usd780/kg






















Stearoyl Vanillylamide is an analog of Capsaicin, a naturally-occurring ingredient found in various species of hot peppers, to be exact, red peppers, which is primarily responsible for the spicy taste. Capsaicin is the main factor for the hot/burning feeling caused by chili peppers. Unlike Capsaicin, however, Stearoyl Vanillylamide is non-pungent, meaning it does not impart the “spicy” or irritative effects of capsaicin, which actually makes it easier to use in powder-form supplements.

Benefits of Stearoyl Vanillylamide

1. Promote fat metabolism for weight loss

2. Improve physical function
    
3. Anti-inflammatory, pain relief and itching

4. Improve skin metabolism for beauty

Main Features:

Weight loss, high safety, no side effects


Glutamine/Guarana Extract/Chromium(Cr)/Alpha Lipoic Acid/L-Carnitine/Chitosan/Creatine/Glucosamine Chondroitin/Dandelion flavonoids


Amino acid

Amino acids are essential components after protein cleavage. They are very important in the growth and metabolism of muscle tissue.

8 essential amino acids: 
Lysine, Methionine, Leucine, Isoleucine, Threonine, Proline, Tryptophan, Phenylalanine

12 non-essential amino acids:
Arginine,Aspartic acid,Asparagine,Cysteine,Glutamine,Glutamate,Glycine,Histidine,Proline,Serine,
Tyrosine

Steroids supplement

Steroids include sterols (such as cholesterol, lanosterol, sitosterol, sterol, ergosterol), bile acids and bile alcohols, steroid hormones (such as adrenocortical hormones, androgens, estrogens), insect ecdysone, Cardiac glycosides and saponin ligands and scorpion venom and so on.

There are also synthetic steroids such as prednisolone, dexamethasonepromote protein synthesis and oral contraceptives.

Functions: promote the secretion of sex hormones, improve the level of competition, increase muscle fat loss

L-Carnitine

L-carnitine derivatives: 
L-carnitine tartrate, 
acetyl L-carnitine hydrochloride, 
acetyl L-carnitine arginine dihydrochloride, 
glycine propionyl L-carnitine hydrochloride

This is an amino acid that promotes fat burning. 
L-carnitine is an energy porter, and it only works with energy consumption of exercise.
The main physiological function is to promote the conversion of fat into energy. 

In 2003, it was recognized by the International Obesity Health Organization as the safest and no side-effect weight loss nutritional supplement.



Chitosan

Source: Chitosan, shrimp and crab shell chitin deacetylation

Applications: Medicine, food, chemicals, cosmetics, water treatment, metal extraction and recycling, biochemistry and biomedical engineering, etc.

Commercial chitosan has three different viscosities depending on its use, ie 
0.7 ~1 Pa·s for high viscosity products, 
0.25 ~ 0.65 Pa·s for medium viscosity products, 
 <0.25 Pa·s for low viscosity products.

Physiological activity: control cholesterol, inhibit bacterial activity, prevent and control high blood pressure, adsorb and excrete heavy metals, immune effect

Application on health foods, complex fatty acids, bile acids, and cholesterol are not absorbed directly from the body, lowering fat, reducing heat absorption
Food grade, industrial grade, water-soluble, special chitosan, special specifications

Chromium(Cr)

It may be the most famous of all fat burning agents on the market. Chromium is a good product that has been proven to help you reduce fat while increasing muscle mass. The best chromium-containing product is Chromium Picolinate


Chromium is a trace element necessary for insulin to function when glucose is metabolized. The lack of either or both may affect the utilization of glucose.

Creatine

Creatine is a nitrogen-containing organic acid naturally present in vertebrates that assists in the energy supply to muscles and nerve cells.

The activities of the human body rely on ATP, that is, adenosine triphosphate to provide energy, and ATP is stored in the human body very little. When exercise, ATP is quickly consumed, and creatine can quickly re-synthesize ATP to supply energy.

Timely supplementation with creatine can effectively increase muscle strength, speed, and endurance. Improve physical fitness and training to prevent fatigue
It is especially necessary for vegetarians to supplement creatine.

Dosage: 500mg-5000mg

Creatine,Creatine Monohydrate, CMH,N-Amidinosarcosine  CreatineHydrate



Dandelion flavonoids 

In the 16th century, Germany used dandelion for "clear blood" and liver congestion. Until now, Switzerland, Poland, Hungary, and Russia still use it as a formal drug.

Role: liver and liver protection, choleretic agents, diuretics (will not filter out potassium) can cause blood pressure to drop, dehydration
Dandelion flavonoids can alleviate local pain and muscle pain

Omega3/6/9 fatty acid

Omega-3: Important omega-3 essential fatty acids including alpha-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), source linseed oil, perilla seed oil, hemp Kernel oil, peony seed oil, sea buckthorn oil, etc.

Omega-6: linoleic acid, arachidonic acid, etc., corn, soybeans, and other plants, pork, beef, lamb, Omega-6 unsaturated fatty acid content is quite a lot. Common borage oil


Omega-9: Oleic acid. Olive oil, linseed oil, evening primrose oil, and sorrel oil. High consumption of olive oil in Mediterranean countries is associated with a lower incidence of breast cancer and heart disease

Ginseng Extract, Ginkgo Biloba Extract

Ginseng root extract

Ginseng stem and leaf extract

Ginkgo Biloba Extract 24.0%Flavones 6.0% lactones



Glucosamine Chondroitin

Classic formula
Glucosamine + chondroitin sulfate + dimethyl sulfone
Glucosamine can help repair and maintain cartilage and stimulate the growth of chondrocytes
Chondroitin sulfate, derived from cartilage such as chicken, cow, pig, etc., can promote articular cartilage regeneration

Dimethyl sulfone: essential for the synthesis of collagen in the human body

Glutamine

It is the most abundant in human muscle tissue and therefore an essential supplement for bodybuilders. Everyone knows that protein helps growth, and glutamine is the most important part of the protein component that helps muscle growth.

Guarana Extract

It is rich in the Amazon River in northern Brazil and is the most well-known in Brazil. It has long been recorded in the rainforest medicinal plants.
Improve energy, lose weight, heart health



Alpha Lipoic Acid

Alpha-Lipoic Acid (ALA) is a mitochondrial compound that is highly involved in energy metabolism. 
ALA is a potent anti-oxidant compound. 
ALA also is an insulin-like substance
Features:
Strengthen liver function
Recover fatigue: increase energy metabolism
Improve dementia
Beauty and anti-aging

Medium Chain Triglycerides(MCT)

Medium chain fatty acids (MCFA) are composed of 6-12 carbon atoms and are relatively low in nature. They are mainly derived from palm oil, coconut oil, milk and so on. Coconut oil contains about 14%, palm oil contains about 7%, and milk and breast milk contain 1%-3%.

Improve the body's energy metabolism, promote fat decomposition, reduce the accumulation

Melatonine(MT)

Melatonin is a hormone in our body that tells you when to sleep
Brain Age

Other sports nutrition ingredients

Phosphate: Improves endurance and works with creatine
Pyruvate: This is a new supplement that is said to help “reduced fat without exercise”
Hedgehog saponin: promotes the production of testosterone. As testosterone promotes protein synthesis, the result is increased muscle growth and strength.
Barium sulfate: Vanadium sulfate is a good supplement that can make your muscles look and feel harder
Whey Protein: Whey is by far the best protein
White Willow Bark Extract: Natural Aspirin





S-Allyl-L-Cysteine(SAC) black garlic

(amy.cheng@cimasci.com)


What is aged black garlic?

Aged Black garlic is a pure natural health food adopting international leading special biological fermentation, screening high-quality garlic (Allium sativum) carefully, fermenting spontaneously after 60-90 days, soft and slippery, sweet and sour taste, black-jelly shape.

This form of garlic has some nutritional differences from traditional garlic and is widely used in high-end cooking applications. Due to the difficulty in producing it and the subsequent cost, it isn’t the most common ingredient to find on a spice shelf, but it does provide a number of unique health benefits. People consume aged black garlic by itself, grounding into a powder, infusing in oil, adding to vegetable dishes when mincing it into sauces or glazes. The flavor of aged black garlic is highly muted, in comparison to white garlic, so a rather large amount is needed to make an impact in most dishes. 

How to make aged black garlic extracts?



Fresh Garlic (Raw material)→Selecting→Peeling →Washing →Fermentation( Moisture, Temperature, and Humidity Control)→Drying→Grinding→Deioned Water  Extract→Centrifugal Separation→Refining→Vacuum Evaporation  Concentration →Precision Filtration→Spray Drying→Testing → Sieve → Packing →Sterilization → Product


 What specifications of aged black garlic extracts we have?


  CS-AGP-001     Aged Black Garlic Powder 10:1                     Odorless
  CS-AGP-002     Polyphenols≥3%                                             Odorless
  CS-AGP-003     S-Allyl-L-Cysteine(SAC)≥1%                  Odorless
  CS-AGP-004     Aged Black Garlic Extract Powder, Ajoene   Odorless
  CS-AGB-001       Aged Black Garlic Bulb
  CS-AGL-001     Aged Black Garlic Extract Liquid≥ 16.0 Brix
  CS-AGL-002     Aged Black Garlic Extract Liquid≥ 32.0 Brix

  OEM services: Aged Black Garlic capsules,soft gel.


Health benefits of aged black garlic extract

The most notable health benefits of black garlic include its ability to protect against chronic disease, boost immunity, prevent cancer, regulate diabetes, and boost heart health, among others.

Prevent Cancer
The compound S-allyl cysteine(SAC) that forms when you blacken garlic has been shown to directly impact the formation of cancerous cells in your body, even more effectively than white garlic. This makes this specialty item even more important for people trying to boost their health through an exotic diet.

Regulate Diabetes
Aged black garlic is even more effective at regulating blood sugar levels. The active ingredients in this herb can help to slow the release of insulin into the body, which is important for diabetic patients and those who are at high risk of developing this condition.

Improve Cardiovascular Health
One of the amino acids found in our body, homocysteine, can actually damage blood vessels walls and compromise out cardiovascular health. Studies have found that aged black garlic is very good at reducing the levels of homocysteine in the blood, subsequently helping to protect our heart health.

Boost Immunity
Garlic is famous for its impact on the immune system, and the same thing is true of aged black garlic. It is known to boost the immune system’s strength and prevent a number of common bacterial and viral infections. It is particularly good for cleaning out the digestive tract and respiratory systems.



Cimascis advantages:

We produce this age black garlic from natural garlic according to GMP standard.
As a large-scale manufacturer, we can supply high-quality products in large quantity.
We could provide strong technical and academic support from our technical team consists of professors and PhDs.



Ajoene(in Garlic)

(amy.cheng@cimasci.com)




Garlic (Allium Satirum L.) is a perennial herb of the family Liliaceae. 
Garlic could be classified into purple garlic and white garlic, large garlic, and small garlic.
Garlic is rich in vitamins, amino acids, proteins, sugars, inorganic salts, and other nutrients. In addition, it contains selenium, barium and other trace elements, vitamin B1, vitamin A, vitamin C, SOD and other natural ingredients with obvious pharmacological activities.

The main active ingredients: Alliin, Allicin, research shows that these sulfur compounds have significant effects in reducing blood fat, improving immunity, bactericidal and antibacterial, anti-aging, promoting blood flow, anti-cancer and anti-cancer.

Black garlic has a soft, non-sticky taste, moderate sweetness, and sourness, no spicy or odor. Moreover, the content of sulfur compounds such as Ajoene and S-allyl-cysteine (SAC) is increased. Therefore, the physiological function of black garlic is greatly improved compared with fresh garlic.

Ajoene



Product name: Ajoene 
Other name:4,5,9-trithiadodeca-1,6,11-triene-9-oxide)
Molecular formula:C9H14OS3
Molar mass:234.4g/mol
Two isomers:(E)-Ajoene;(Z)-Ajoene
Z-ajoene is more active than E-ajoene due to the presence of cis-carbon double bonds



The production process of ajoene in garlic:

Fresh garlic contains alliin (C6H11O3NS) and alliinase, which are present in the cytoplasm and vacuole, respectively. When garlic is broken, alliin is converted to allyl sulfenic acid (C3H6OS) and dehydroalanine (C3H5O2N) by the action of alliinase. Allyl sulfonic acid is produced allicin (ie, two Allyl thiosulfinate, C6H10OS2)by disproportionation reaction. Allicin is extremely unstable and will be further decomposed into diallyl sulfide compounds (C6H10Sn, n=1~6), dithiane (C6H8S2) and ajoene (C9H14OS3, E, and Z). Therefore, it can be said that ajoene in garlic is the second degradation product of alliin.



Factors affecting the production of ajoene:
  
 Enzymatic hydrolysis time 5-30min
 pH5.0-6.5
 Temperature 4—35°C
 Solvent type Use:non-polar or weakly polar solvents (such as n-hexane, vegetable oil, etc.), polar solvents (such as methanol, ethanol, etc.)

The physiological function of ajoene

Ajoene is a highly biologically active sulfide that has the effects of preventing cardiovascular disease, anti-oxidation, anti-thrombosis, lowering blood pressure, reducing the incidence of Alzheimer's disease, resisting pathogenic bacteria, anti-virus, and improving immunity.

Ajoene has no spicy odor of garlic and is more biologically active than ether sulfur compounds and dithiene. Therefore, ajoene is easily accepted by people and has greater application potential in the production of medicines and health products.


Reference:The production process of ajoene in black garlic and its anti-hypertensive effect,by Guangyong Zhou,Prof.Yelian Miao