Pterostilbene and Resveratrol
(amy.cheng@cimasci.com)
Resveratrol (3,5,4’-trihydroxy-trans-stilbene), is a stilbenoid, a type of natural phenol. As one of the popular anti-aging supplements was discovered in 1963 when it was found in Japanese Knotweed. Now sources of resveratrol naturally from knotweed, grapes skin, etc.
Pterostilbene (trans-3,5-dimethoxy-4-trihydroxystilbene) is a stilbenoid chemically related to resveratrol, is the main antioxidant component of blueberries, and Pterocarpus marsupium heartwood. Some studies suggest it may be more useful for health than its close relation, so it may be as super resveratrol.
Name
|
Resveratrol
|
Pterostilbene
|
CAS No.
|
501-36-0
|
537-42-8
|
Other names
|
trans-resveratrol
|
trans-pterostilbene
|
Molecular formula
|
C14H12O3
|
C16H16O3
|
Molecular weight
|
228.24
|
256.30
|
Molecular
structure |  |  |
Specification
|
98%min white powder
|
99%white powder
|
Related products
|
Natural Resveratrol;
grape skin extract powder;
Micronized Resveratrol Powder;
Acetyl-resveratrol;
Water-soluble resveratrol;
Oxyresveratrol
|
Natural Pterostilbene;
Trans-Pterostilbene;
3'-Hydroxypterostilbene
|
Difference between Pterostilbene and Resveratrol
Pterostilbene and resveratrol both have the same role in the plant’s defense system. “Resveratrol is one of the main phytoalexins in grapes, pterostilbene in blueberries,” explained Jeremy Bartos, Ph.D., pTeroPure product manager for ChromaDex of Irvine, CA. “The only difference between the two is the presence of two methoxy groups in pterostilbene (resveratrol has three hydroxyl groups, pterostilbene has one along with the two methoxys).
It’s the methoxy groups that make all of the difference when it comes to utilizing these compounds in the human body. “Resveratrol has two things going against it,” said Dr. Bartos. “One is the fact that without the methoxy groups it is not as lipophilic (oil-soluble) as pterostilbene, so it’s cellular uptake is much less than pterostilbene - pterostilbene can be taken through the cell’s lipid bi-layer rather easily.”
The second difference has to do with how pterostilbene is filtered through the human liver. “The liver acts as the gatekeeper to the body; it filters everything that comes through and compounds it does not recognize (such as pharmaceuticals, plant chemicals, and toxins) it will tag for elimination from the body,” said Dr. Bartos. “In the case with stilbenes such as resveratrol and pterostilbene, the liver will typically glucuronidated (add a glucuronic acid molecule, a compound very similar to glucose) or sulfate any free hydroxyl groups it can find. Since resveratrol has three hydroxyl groups it is tagged for elimination much quicker and easier than pterostilbene with only one hydroxyl group, leading to a half-life in the blood of ~14 minutes compared to ~105 minutes for pterostilbene.”①
Pterostilbene offers the following advantages over resveratrol:
Superior bioavailability
Significantly longer half-life
Greater cellular uptake
Greater oral absorption and metabolic stability ②
How Pterostilbene and Resveratrol Work Together
Scientists have found that resveratrol activates genes near the beginning of the molecular cascade precipitated by caloric restriction. These, in turn, activate a broad array of disease-preventing genes. In essence, resveratrol’s beneficial genetic action takes place “upstream”. Pterostilbene directly activates genes “downstream” from the sites of resveratrol’s action. This complements resveratrol’s ability to help prevent cancer and diabetes, and support healthy blood lipids. Acting together, resveratrol and pterostilbene produce potent longevity-promoting effects across the cycle of gene expression through complementary mechanisms.③
Where to buy materials of Pterostilbene and Resveratrol powder
Wuxi Cima Science Co., Ltd, with more than 10 years’ experience in researching and producing trans-pterostilbene and trans-resveratrol, is a reliable manufacturer who exports bulk quantity to worldwide countries.
Documents:certificate of analysis,specifications sheet,manufacturing flow chart,etc,available upon your request.
Reference Price of Pterostilbene and Resveratrol
Pterostilbene: is usd410-usd500/kg
Resveratrol: is usd210-usd260/kg
Documents:certificate of analysis,specifications sheet,manufacturing flow chart,etc,available upon your request.
Reference Price of Pterostilbene and Resveratrol
Pterostilbene: is usd410-usd500/kg
Resveratrol: is usd210-usd260/kg
Reference:
3. by Tiesha D. Johnson,A Novel Method to Simulate the Genetic Effects of Caloric Restriction,The “Other” Resveratrol
