4/10/2019

Magnesium L Threonate Price

What is Magnesium L Threonate? 

Magnesium L-Threonate is a natural nutritional supplement containing the L-Threonate form of magnesium that can be used to normalize Mg levels in the body with neuroprotective and nootropic effects. Therefore it can significantly improve memory, learning, cognition.
According to Wikipedia, Magnesium is a mineral that helps our body stay healthy. It is crucial for many functions in the body, which closely relates to energy metabolism and protein synthesis. It also contributes to elevating brain function, bone health, heart, muscle activity.

Magnesium forms available

There are many magnesium salt forms, for instance, magnesium sulfate, magnesium citrate, magnesium oxide, magnesium glycinate, and magnesium ascorbyl phosphate,  Etc.
However, in one of the research papers published in 2010, MIT Massachusetts Institute of Technology)researchers found Magnesium l Threonate was the only magnesium form that could go through the blood-brain barrier. It results in its unique absorption comparing with other magnesium salts.

Foods rich in Magnesium

Magnesium ranks the fourth spot in the vital minerals of the body (after sodium, potassium, calcium). Magnesium supplement links to many benefits, including better blood sugar regulation, improved sleep, relief from constipation. It is found naturally in foods like nuts, leafy green vegetables, milk products.
Some magnesium-rich foods as below:
· Kidney beans
· Oatmeal
· Peanut butter
· Potato with skin
· Pumpkin
· Raisins
· Spinach
· Whole grain bread
· Almonds
· Black beans
· Brown rice
· Cashews
· Shredded Wheat
· Soy milk

Magnesium Deficiency

Magnesium is crucial for various functions in the body and plays a significant role in our overall health.
Magnesium deficiency seems not to happen due to low dietary intake in healthy people. However, it is common under some certain health conditions, such as chronic alcoholism. Some medications can also reduce your magnesium levels.
Magnesium deficiency, usually called hypomagnesemia, is an often neglected health problem.
Magnesium deficiency co
· common symptoms usually react
·  as nausea
· vomiting
· loss of appetite, fatigue

Magnesium VS Magnesium L Threonate

Most metals including in magnesium are cations or charged ions which are very unstable. Meanwhile, it's hard for the body to absorb independent magnesium. Overall, magnesium supplements mostly are chelates that combine magnesium with other anions substances in the market.
Magnesium L-Threonate is a stable form with the magnesium cation linking to the L Threanoic acid (a metabolite of VitaminC) anion. Some investigations indicate that L-Threonate can enhance mineral uptake greatly. In general, Magnesium L Threonate is the best magnesium supplement with excellent stability and easily absorbency.
In recent years, more and more brands try to supply the best Magnesium l Threonate supplement.

Mechanism of Action of Magnesium L Threonate

What is the essential difference between Magnesium Threonate and other magnesium forms? Usually, there is an inner membrane called endothelial cells in the human body's blood vessels. There is a "void" between these cells, allowing substances in the blood to enter the cell in most parts of the body.
Nevertheless, when it comes to the brain, there is not any lacuna. Very few substances can pass through, even most medications are confining, but Magnesium Threonate can go through the barrier and affect the brain with its distinct penetrability.
Taking Magnesium L-Threonate can increase the absorption of magnesium by 15%, much higher than other supplements.
Besides, as we mentioned above, because of the penetrating power, MIT scientists found Magnesium Threonate could improve both the plasticity and activity of our brains' synapses. It makes neurons communicate much more effectively. It is seen visibly within the hippocampus, an area of the brain that's responsible for memory. It's believed that this effect is due to increasing cerebrospinal fluid of the brain.

Magnesium L Threonate benefits

Magnesium L-Threonate for brain health

There have been some discussions based on Magnesium L-Threonate vs. Magnesium Sulfate; both of these compounds can increase the memory. However, Magnesium L-Threonate tends to be safer.
Magnesium L Threonate can improve nerve functioning while boosting mental energy. Then it leads to a better ability to learn and create new neural pathways. Magnesium Threonate also can reduce anxiety, symptoms of depression and sleep disturbances. The supplement is commonly used to promote relaxation, calm the mind and has been found useful for mild to moderate depression in adults.

Magnesium L Threonate for preventing hair loss

Two potential causes result in hair loss. One is an imbalance of excess calcium with magnesium. The other is poor nutrition and circulation on the top of the head. It will lead to poor hair growth and condition, whereas an increase in blood flow to this area may enhance hair growth. Magnesium L Threonate get both two sides ability, Magnesium works as the mineral balance, L Threonate pass through the blood-brain barrier to boost the blood circulation.

Magnesium L Threonate for bone health

Magnesium and calcium deficiency leads to conditions as osteoarthritis.
As we age, magnesium must keep an appropriate balance with calcium to maintain healthy bone density and bone health.
Limited clinical trials have found that it may prevent and possibly reverse osteoporosis if people take daily L Threonate Magnesium over long periods. Reportedly: women who supplemented their diets with Magnesium Threonate over two years had fewer fractures and a decreased rate of bone loss.

Magnesium L-Threonate for good heart

Research has discovered that people with a higher intake of Magnesium L Threonate have a lower risk of heart disease. Scientific investigations have also indicated that the higher the magnesium content in the blood, the lower the risk of coronary artery disease. Additionally, it has been approved that higher levels of magnesium can lower levels of the inflammatory marker C-reactive protein, which associates with heart problems.

Magnesium L Threonate side effects

The reported side effects of magnesium L-Threonate are headaches, drowsiness, blood pressure, severe brain fog, an irregular heartbeat or a feeling of increased blood flow to the head.
Another side effect of magnesium supplements is digestive upset.
Please avoid intake Magnesium L Threonate supplements if you have issues with your kidneys. Because too much magnesium will overwhelm your kidneys.

Magnesium L Threonate daily dosage

Is L Threonate Magnesium a safe supplement?
Of course, it is. We need to follow the recommended dietary safe daily dosage.
Adult men 400-420mg/day
Adult women 310-320 mg/ day.

Where to buy Magnesium L Threonate powder?

At Cima Science Co.LTD, both L Threonate Magnesium bulk powder 98% and Magnesium L-Threonate capsules are available.


2/27/2019

Oleylethanolamide VS cannabinoid anandamide

The effects of OEA were first studied because it shares similarities with another chemical, a cannabinoid known as anandamide. Cannabinoids are related to the plant Cannabis, and anandamides present in the plant (and marijuana) can increase a person’s desire to snack by triggering a feeding response. According to Wikipedia, Oleoylethanolamide is the monounsaturated analog of the endocannabinoid anandamide. Although OEA has a chemical structure that is similar to anandamide, its effects on eating and weight management are different. Unlike anandamide, OEA acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis.


Structures of various fatty-acid ethanolamides: Oleoylethanolamide (OEA), palmitoylethanolamide (PEA) and anandamide (arachidonoylethanolamide, AEA). (Cima Science Co., Ltd is the only manufacturer of bulk raw materials of OEA, PEA, and AEA in China, if you need sample and price quote, please drop us an email with amy.cheng@cimasci.com)
OEA:
Make sure that our OEA is a raw material in powder form instead of capsules or tablets. Some companies use Oleoylethanolamide powder (standardized to 15% Oleoylethanolamide) or Oleoylethanolamide oleic acid 50% in their finished products. The specifications of Cima OEA is 90% min, up to 95%, quality is satisfied among our buyers in the United States and Europe.
PEA: palmitoylethanolamide (Cas no.544-31-0) powder, ultra micronized PEA powder
SVA: Stearoyl Vanillylamide (Cas no.58493-50-8) powder
Read more details at https://cimasci.com/products/oleoylethanolamide/

2/22/2019

Safety of Nicotinamide Riboside(NR)

Safety of Nicotinamide Riboside(NR)


The two major forms of vitamin B3, nicotinic acid and nicotinamide, are together commonly known as niacin, and constitute the best well-known NAD+ precursors. Nicotinamide riboside (NR) is a single chemical moiety containing nicotinamide and ribose and, because it is a precursor of nicotinamide adenine dinucleotide (NAD+ ), is considered to be a form of vitamin B3 (reviewed in Chi and Sauve 2013; Penberthy and Kirkland, 2012; Bogan and Brenner, 2008). 


Intake of nicotinic acid at doses of 50 mg/day and higher consistently results in undesirable side effects, including vasodilation effects (flushing) and pruritus (itching), which can occur within 30 minutes following oral administration (Guyton and Bays, 2007), whereas NR and nicotinamide are not associated with these adverse effects. NR may not cause flushing because just like nicotinamide, it does not bind GPR 109a, the high-affinity G-protein coupled receptor that is believed to play an important role in mediating the vasodilatory effects of nicotinic acid (Canto et al. 2012).                                                                            
--GRAS-NR-ChromaDex

Nicotinamide riboside chloride Price


Nicotinamide riboside chloride

CAS NO.:23111-00-4
Synonyms:Nicotinamide riboside chloride;3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride;3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride;3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium chloride;Nicotinamide B-D Riboside Chloride(WX900111);Nicotinamide Riboside.Cl 
Chemical Name:3-(amiocarbonyl)-1-β-D-ribofuranosyl-pyridinium cloride (1:1)
Molecular Formula:C11H15N2O5.Cl
Molecular Weight:290.7
Reference price:usd1300-usd1500/kg






















Benefits of Nicotinamide riboside chloride


  • Delay aging
  • Improve cardiovascular health
  • Improve brain health
  • Improve fat metabolism
  • Improve the body's resistance to cancer cells
  • Detoxification
  • Beauty effect



  • Similar products:

    NMN:(β-Nicotinamide Mononucleotide, CAS NO.1094-61-7),purity >98%
    NR:(Nicotinamide Riboside Chloride,CAS NO.23111-00-4),purity >97%
    NAD+:(β-NAD+,food grade,CAS NO.53-84-9),purity >98%
    NADH:(β-Nicotinamide Adenine Dinucleotide, CAS NO. 606-68-8) 
    Nicotinamide adenine dinucleotide phosphateoxidized (NADP+) and reduced (NADPH) 




    Nicotinamide riboside (NR) 1-(β-D-Ribofuranosyl)nicotinamide N-Ribosylnicotinamide CAS 1341-23-7

    Nicotinamide riboside (NR) is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

    Chemical information:
    Nicotinamide riboside (NR)
    Other names: 1-(β-D-Ribofuranosyl)nicotinamide; N-Ribosylnicotinamide
    CAS Number:1341-23-7
    MF: C11H16N2O5
    MW:256.26


    Cimasci. offer Nicotinamide riboside (NR) with stocks, fine powder 

    Similar products:

    NMN:(β-Nicotinamide Mononucleotide, CAS NO.1094-61-7),purity >98%
    NR:(Nicotinamide Riboside Chloride,CAS NO.23111-00-4),purity >97%
    NAD+:(β-NAD+,food grade,CAS NO.53-84-9),purity >98%
    NADH:(β-Nicotinamide Adenine Dinucleotide, CAS NO. 606-68-8) 
    Nicotinamide adenine dinucleotide phosphateoxidized (NADP+) and reduced (NADPH)


    2/19/2019

    What is alliin?

    Alliin 98%

    Synonyms: (2R)-2-amino-3-[(S)-prop-2-enylsulfinyl]propanoic acid, 3-(2-Propenylsulfinyl)alanine, (S)-3-(2-Propenylsulfinyl)-L-alanine, 3-((S)-Allylsulfinyl)-L-alanine, S-Allyl-L-cysteine sulfoxide, SACS, S-allyl cysteine sulfoxide, New-Gar®, allicin precursor, S-allyl cysteine sulphoxide
    Botanical source: Allium sativum L.
    Part Used: Garlic Bulb
    CAS Number: 556-27-4
    Molecular FormulaC6H11NO3S
    Specification: 98% min
    Standard: Enterprise Standard
    Appearance: White to yellowish powder
    Solubility: Soluble in water
    Benefits: cardiovascular health, Maintains healthy cholesterol, anti-inflammatory, Myocardial infarction,
    Applications: Food additives, supplements, drugs, medicines
    Dosage: Vary upon different applications
    Wuxi Cima Science Co., Ltd is a professional manufacturer of nutritional raw ingredients specializing in garlic active ingredient series products, such as alliin, allicin, ajoene, etc. Commercial production and the ready stock is available.
    More details please check https://cimasci.com/products/alliin-98/




    Polydatin Price

    Polydatin

    Plant description

    1. Plant source: The rhizome of the Polygonum cuspidatum Sieb. et Zucc.
    2, origin: distributed in central and southern China, produced in Hunan, Hubei, Jiangsu, Zhejiang, Jiangxi, Fujian, Henan, Shaanxi, Sichuan, and other places. Born in the valley, by the river or on the shore.

    Product description

    CAS No.: 27208-80-6
    English name: Polydatin, Piceid
    Chemical name: 3-Hydroxy-5-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl-beta-D-glucopyranoside
    Composition Category: Stilbene steroids
    Traits: white powder (98%)
    Specification: 98% (HPLC)
    Polydatin Price:usd400-usd475/kg
    Molecular weight: 390.38
    Molecular formula: C20H22O8
    Structure:







    Pharmacological effects:
    (1) hypolipidemic and anti-lipid peroxidation
    Studies have found that sublingual Polydatin 2.2mg.kg / d for 3 consecutive days, can increase the elevated serum cholesterol, low-density lipoprotein /high-density lipoprotein (LDL / HDL) ratio and hematocrit to normal, It also has a tendency to reduce the high shear rate and the low shear rate of whole blood. Another study has determined the degree of lipid peroxidation under the influence of exogenous free radicals and found that Polydatin can improve the stability of lipid membranes and has significant resistance. Lipid Peroxidation.

    (2) Effects on vascular smooth muscle cells
    The effect of Polydatin on rat vascular smooth muscle cells and human umbilical cord arterial smooth muscle cells showed that Polydatin has a two-way regulation of intracellular calcium pH. Under normal conditions, Polydatin not only promotes vascular smooth muscle extracellular calcium ions into cells but also induces cells. Intracellular calcium release, increase intracellular free calcium, increase PH to increase vascular tone, reduce intracellular calcium concentration during shock and reduce intracellular pH to reduce vascular tone, dilate blood vessels, and promote extracellular sodium ion inflow Cells are depolarized to regulate blood vessels, which may be involved in the opening of sodium and potassium channels and are inversely regulated by the adrenergic receptor H2 receptor system and the guanylate cyclase system.

    (3) The effect on cardiomyocytes
    It has been reported that studies on rat cardiomyocytes indicate that the cardiotonic effect may directly enhance myocardial contractility by increasing the concentration of free calcium ions in individual cells. This effect of Polydatin makes it theoretically superior to the digitalis of the digitalis, which not only makes the myocardial contraction more powerful but also makes the myocardial relaxation more thorough, thus greatly improving myocardial work efficiency.

    (4) Hang platelet aggregation and improvement of microcirculation
    Studies have found that Polydatin inhibits arachidonic acid, adenosine diphosphate, and adrenaline-induced rabbit platelet aggregation in vitro and in vivo, which is stronger than aspirin, indicating that anti-thrombosis of Polydatin is closely related to stronger anti-platelet aggregation. Related. This has a certain application value for the prevention and treatment of thromboembolic diseases.

    (5) Antioxidant and liver protection
    Oxygen free radical production is an important mechanism for causing multiple organ failure. Polydatin has significant antioxidant protection against the liver and inhibits the accumulation of lipid peroxides in the liver. Studies have shown that Polydatin can significantly inhibit the oxidative damage of mouse hepatocytes induced by hydrogen peroxide in a certain concentration range, and can improve superoxide dismutase (SOD) and glutathione peroxidation in hepatocytes. (GSH-Px) activity, reduce GSH consumption, reduce malondialdehyde (MDA) content, inhibit nitric oxide synthase (NOS) activity, reduce nitric oxide (NO) production and oxidation, thereby reducing oxide pairs Damage to liver cells.

    Applications: In recent years, there have been more and more pharmacological and applied researches on polydatin. Polydatin and its products are widely used in medicine, beauty, health care, food, and other fields.

    Recommended dosage:
    Dietary supplements: As a food supplement for the antioxidant and health-promoting cardiovascular system, the recommended dose is 50-100 mg per day based on the active ingredient polydatin.


    Wuxi Cimasci. could offer Polydatin 98%powder in stocks and formula matching with Palmitoylethanolamide (PEA), welcome your kind inquiry!