What is Dihydroquercetin (Taxifolin)?

Larch Root Extract

Botanical Name:Larix gmelinii (Rupr.) Rupr.

Chemical family: Bioflavonoids

Plant sources: Pinaceae plants like Larch, Douglas fir, Jinliu Branch plants like Lines of trees, Rosaceae plants like Wild black cherry, wood, Aralia grassroots, Lacertaceae plants like Pistacia chinesis Bunge, Labiatae plant like Anbo forskohli leaves.

Active Ingredient: Dihydroquercetin (Taxifolin) 90%-98%

Other Ingredients: aromadendrin, eriodictyol, quercetin, naringenin, pinocembrin

Physical properties: fine light yellow powder, soluble in ethanol, acetic acid, boiling water, slightly soluble in cold water, almost insoluble in benzene. The extract used to root.

Dihydroquercetin

CAS: 480-18-2

Molecular formula: C₁₅H₁₂O₇

Molecular weight: 304.25

Others:taxifolin(2r,3r)-3,3',4',5,7-pentahydroxyflavanone;(2r,3r)-Dihydroquercetin                                              

 Dihydroquercetin, also known as Taxifolin or taxodium, belongs to vitamin p, is a kind of dihydro ketone alcohol compounds. First, it could affect the metabolism of fat by regulating the activity of enzymes, inhibiting in synthetic of liver fat; it is obviously inhibiting esterification of cholesterol in liver cancer cells and synthesis of triacylglycerol and phospholipids, effectively activate phosphodiesterase. Second, it is the role of larger lymphocytes can inhibit lymphocytic disease. The third can effectively inhibit the growth of squamous cell carcinoma and leukemia cells. The fourth with a significant antioxidant effect. The antioxidant power of dihydroquercetin is 3-5 times that of quercetin, which is widely used shows by researches. Fifth, reduce intestinal peristalsis, inhibition of aldose reductase, reduction of cytochrome c, mitochondrial oxidation of the respiratory chain inhibition, reduce blood lipids, protect the vessel wall, anti-inflammatory, the role of the protection of the stomach.

At present, the main application in three areas: First, the food industry, that is, food additives. Its antioxidant capacity, especially in the high-dose test did not find it on the fetus teratogenic, mutagenic, allergic effects, can be used for vegetable oil, animal fats, dry milk powder, fat candy heart children, can extend its validity 2-3 times, and improve food properties; Second, the pharmaceutical industry. Such as the treatment of the human circulatory system, that is, to enhance the flexibility of the vessel wall; such as the manufacture of radiation therapy, radiation effects of drugs, manufacture anti-aging drugs, treatment of genetic abnormalities and improve immune function drugs, Cells and cause cancer cells kill each other, and no effect on normal cells; anti-virus, anti-inflammatory significantly. At the same time can be used as pharmaceutical intermediates. Third, industrial. For the anti-seismic, stabilizer, paint antioxidants, rocket fuel, engine oil additives.

Dihydroquercetin as health food products mainly functions with:

1.Antioxidant properties: Dihydroquercetin will remove free radicals in the body, anti-oxidation, anti-aging.

2.Protection of capillary performance: Dihydrogenated quercetin can maintain cells, membranes and other human tissues and organs; consolidate blood vessels and capillaries, regulate blood lipids.

3. Anti-inflammatory properties: prevention and treatment of inflammation, prevent edema.

Protection of liver function: to prevent the virus and toxins on the liver damage.

4.Anti-allergy: the allergen removed from the human body and improve the body's resistance to allergens.

5.Radiation protection: to promote the rehabilitation of people after radiation.

6. Improve the reproductive capacity of performance: to improve male and female reproductive capacity, promote gonadal function, Bushen impotence.

Pharmacological activity:

1. Anti-cancer: the mouse leukemia P388 activity, 150 and 100mg / kg life extension rates were 40% and 37%.

2. Antibacterial: Staphylococcus aureus, Escherichia coli, Shigella and Salmonella typhi have a strong antibacterial effect

Application: Dihydric quercetin can be used as high-grade food raw materials, health products and pharmaceutical raw materials, can also be used in alcohol, to eliminate the adverse reactions after drinking.

(amy.cheng@cimasci.com)

Alpha GPC Softgel Price

Cima Pure Alpha GPC Softgel

(amy.cheng@cimasci.com)

Alpha glycerylphosphorylcholine(also called choline alfoscerate and Alpha GPC)is a precursor to the neurotransmitter acetylcholine, which is naturally present in all the body's cells and plays important roles in supporting memory and cognition in the brain.

English name: L-Alpha glycerylphosphorylcholine, alpha-GPC, choline alfoscerate

CAS NO. :28319-77-9

Formula weight: C₈H₂₁NO₆POH

Molecular weight: 275.24

Cima manufacture Alpha GPC and provide with Alpha GPC 50%common powder;50%Not-deliquescent powder;85%liquid;99% powder; Alpha GPC capsules...

All products with superior quality and competitive price!
Now Cima have developed a new specification of Alpha GPC: pure Alpha GPC Softgel

Supplement Facts

Serving size:1 Softgel
Servings per container: 100
Specification: 1000 mg 15%

Why you could choose pure Alpha GPC Softgel?

1.Unique
2.Convenience
3.Competitive

Nigella Sativa Extract 5.0% 10.0% Thymoquinone

Nigella sativa seed Extract ---Thymoquinone

What is Nigella sativa seed?

Also known as the Black seed, black cumin, kalonji seeds and Haba al-barakah (Arabic phrase)

Originated from the Mediterranean region and has been used by people for thousands of years.

Black seed also has a beautiful name -The Persian Gems. This annual plant has three different species Nigella Sativa, Nigella Damascena, and Nigella Glandulifera. The different planting area lends to diverse appearances and various active ingredients in them.

Black Seed is considered to be the greatest healing herb of our time and it has been much neglected. It is being used to strengthen the immune system, fight and irradiate Prostate Cancer and other tumors, purify the blood and increase longevity.

Glorious History

From ancient to modern times, from the eastern continent to the western sea, the miraculous functions of Black Seed are acclaimed by the beneficiaries anywhere.

The Hadith of the Prophet from Sahih Bukhari describes black seed as “a cure for every disease except death”.

The oil is recorded as the Pharaoh Oil in the tomb of Tutankhamun, Egypt.

Even the ancient Chinese Medical book showed it’s an irreplaceable effect on the healing of cancers.

There was an even more remote application of black seed as a flavoring in cook or bake. When taking black seed, the immunity and resistance of eaters were greatly improved.

Current Product Form In the Market

1.Cold Press Oil

2.Volatile Oil

3.Extract Powder(Capsule)

4.With Honey

5.Blending Oil

6.Animal Feed Additive

Active Ingredients and Indications

There are more than 100 kinds of components in the Black Seed 69 of which have been identified by scientists. The interaction of these ingredients makes the black seed a better immunity booster than any single ingredient.

1.Thymoquinone and nigellone

These two volatile oils have anti-spasmodic and broncho-dialating properties.  They also work as a natural antihistamine.

2.Thymohydroquinone

Thymohydroquinone has been proved to act as a acetylcholinesterase inhibitory which could help dealing with Alzheimer dementia

3.Β-Elemene

Elemene is the main active ingradient of Curcuma Aromatica Salisb with anti-tumor effect.EIemene can significantly improve patients' quality of life, with a broad anti-tumor spectrum, curative effect, and mild side effects.

4.p-cymene

P-cymene have relaxant effect in smooth muscle of trachea making it a good choice for asthma.

We offer

1.All specifications of Black Seed cold press oil:

Cold Press Oil

0.5%-5% Thymoquinone

2.All specifications of Black Seed powder extract(including capsules):

1-10% Thymoquinone

3.Blinding Oil:

Immune booster-with garlic oil

Anti-infection-with oregano oil

Anti-cancer-with camellia oil

EFA supplement with flax seed oil and seabuckthorn seed oil

......

4.Pure Thymoquinone:

98% Thymoquinone

5.Whole seed Softgel

Softgel with all ingredients of black seed including both powder and oil.

What is Oxaloacetic acid(OAA) ?

What is Oxaloacetic acid(OAA)?

Oxaloacetic acid is a dicarboxylic acid that is a substrate for the enzymes malate dehydrogenase and oxalacetate decarboxylase when the oxaloacetic acid is in its anionic form oxaloacetate.

Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals.

Chemical profile

Chinese name:草酰乙酸

English name:Oxaloacetic acid

Other name:OAA, oxobutanedioic acid, Oxalacetic acid,benaGene, Ketosuccinic acid

2-Oxosuccinic acid, Ketosuccinic acid, Oxaloacetate,3-carboxy-3-oxopropanoic acid

CAS No.:328-42-7

Molecular Formula: C₄H₄O₅

Molecular Weight:132.1

Specification:98%

Appearance: White crystalline powder

Applications: Dietary supplements, medicines, skincare cosmetics

 

Functions of Oxaloacetic acid

Oxaloacetic acid is a very important intermediate in metabolism. The compound is involved in the citric acid cycle for energy production within the cell.

Many experimental and studies have shown it plays a prominent role in life extension, anti-aging, blood sugar regulation, protect brain health, improved sleeping and energy etc.

•  Life extension&Anti-aging

Oxaloacetic acid as a nutritional supplement,and could increase lifespan in animals. The research out of UCSD and UCLA in "Aging Cell" documents that excess oxaloacetate supplemented to C.Elegans,flys causes an increase in lifespan of 25%.Also, some related article strongly suggests that the molecular pathways activated by oxaloacetate supplementation are the same pathways as are activated in dietary restriction.The mechanism is the ability of oxaloacetate to mimic the calorie restricted metabolic state (but without the need to cut calories) and there is no side effect.

A famous brand-benaGene contains patented "Thermally Stabilized Oxaloacetate" and Vitamin C.Oxaloacetate is a natural energy molecule that is critical to human metabolism and proper cellular function.

• Blood Sugar Regulation 

Some researchers from Japan isolated oxaloacetic acid was able to reduce blood sugar levels in mice. It was tested in humans and determined to be effective in a majority of participants with both two different types of diabetes. Later through infrared spectral analysis, and created a sodium-based form of oxaloacetic acid, they discovered that it significantly lowered blood sugar levels in both normal and diabetic animals.

• Other functions:

Anti-cancer & Anti-tumor

Protect brain health

Improving sleeping & energy

Maintenance weight

Cima Oxaloacetic acid（OAA）

Oxaloacetic acid,there are four ways to generation:

•  Generated by phosphoenolpyruvate (PEP)
•  Generated by Malic acid
•  Generated by Pyruvic acid
•  Generated by Aspartic acid

Cima Oxaloacetic acid, is generated by Aspartic acid through enzymatic catalytic under controlled temperature.It has the following typical characteristics:

• Thermal stability,safety to ship
• Enzymatic produce,high specificity
• Mass manufacturing,supply stable
• Reasonable price,professional services

Now with its developing, the oxaloacetic acid use as a supplement in energy production, brain-boosting, anti-cancer..... So the prospects are wonderful!

Oxaloacetic acid dosage

There is no recommendation for the dosage of oxaloacetic acid. However, the supplements containing stabilized oxaloacetic acid on the label shows that is100 mg each day in capsule form, usually combined with vitamin C and other natural ingredients in the market.

Oxaloacetic acid caution & storage

The storage stability is largely depends on the purity and the contaminants present in oxalacetic acid. It is unstable in solution,decomposing to pyruvate by decarboxylation over a period of hours (room temperature).Oxalacetic acid may decompose in solution even at 0°C.So oxalacetic acid is recommended to be stored and ship below 10°C, however lower quality materials and long term storage term require storage temperatures below -10°C.

Where to buy Oxaloacetic acid?

Cimasci offering oxaloacetic acid with high quality and good price.

Some similar products like PQQ,Pterostilbene, Resveratrol, Cycloastragenol, etc.

Contact:Wuxi Cima Sciecne Co,.Ltd

Email:amy.cheng@cimasci.com

 

Olive Leaf Extract oleuropein 40% hydroxytyrosol 98%

Olive leaf extract

Product name: Olive leaf extract

Introduction: it is extracted from olive leaf material contains powerful antioxidant compounds, such as oleuropein, hydroxytyrosol.

Active Ingredients: Oleuropein, Hydroxytyrosol

Specification: 10% -40% oleuropein, 1% -98% hydroxytyrosol

Appearance: brown fine powder

Features:

1. oxidation resistance

2. against cardiovascular disease

3. good antibacterial activity

Application: Used in medicine, health foods supplement and cosmetic.

Storage: Stored in a cool and dry condition, get away from direct sun.

Shelf life:2 years if stored properly.