Glutamine/Guarana Extract/Chromium(Cr)/Alpha Lipoic Acid/L-Carnitine/Chitosan/Creatine/Glucosamine Chondroitin/Dandelion flavonoids

Amino acid

Amino acids are essential components after protein cleavage. They are very important in the growth and metabolism of muscle tissue.

8 essential amino acids: 

Lysine, Methionine, Leucine, Isoleucine, Threonine, Proline, Tryptophan, Phenylalanine

12 non-essential amino acids:

Arginine,Aspartic acid,Asparagine,Cysteine,Glutamine,Glutamate,Glycine,Histidine,Proline,Serine,

Tyrosine

Steroids supplement

Steroids include sterols (such as cholesterol, lanosterol, sitosterol, sterol, ergosterol), bile acids and bile alcohols, steroid hormones (such as adrenocortical hormones, androgens, estrogens), insect ecdysone, Cardiac glycosides and saponin ligands and scorpion venom and so on.

There are also synthetic steroids such as prednisolone, dexamethasone, promote protein synthesis and oral contraceptives.

Functions: promote the secretion of sex hormones, improve the level of competition, increase muscle fat loss

L-Carnitine

L-carnitine derivatives: 

L-carnitine tartrate, 

acetyl L-carnitine hydrochloride, 

acetyl L-carnitine arginine dihydrochloride, 

glycine propionyl L-carnitine hydrochloride

This is an amino acid that promotes fat burning. 

L-carnitine is an energy porter, and it only works with energy consumption of exercise.

The main physiological function is to promote the conversion of fat into energy. 

In 2003, it was recognized by the International Obesity Health Organization as the safest and no side-effect weight loss nutritional supplement.

Chitosan

Source: Chitosan, shrimp and crab shell chitin deacetylation

Applications: Medicine, food, chemicals, cosmetics, water treatment, metal extraction and recycling, biochemistry and biomedical engineering, etc.

Commercial chitosan has three different viscosities depending on its use, ie 

0.7 ~1 Pa·s for high viscosity products, 

0.25 ~ 0.65 Pa·s for medium viscosity products, 

 <0.25 Pa·s for low viscosity products.

Physiological activity: control cholesterol, inhibit bacterial activity, prevent and control high blood pressure, adsorb and excrete heavy metals, immune effect

Application on health foods, complex fatty acids, bile acids, and cholesterol are not absorbed directly from the body, lowering fat, reducing heat absorption

Food grade, industrial grade, water-soluble, special chitosan, special specifications

Chromium(Cr)

It may be the most famous of all fat burning agents on the market. Chromium is a good product that has been proven to help you reduce fat while increasing muscle mass. The best chromium-containing product is Chromium Picolinate

Chromium is a trace element necessary for insulin to function when glucose is metabolized. The lack of either or both may affect the utilization of glucose.

Creatine

Creatine is a nitrogen-containing organic acid naturally present in vertebrates that assists in the energy supply to muscles and nerve cells.

The activities of the human body rely on ATP, that is, adenosine triphosphate to provide energy, and ATP is stored in the human body very little. When exercise, ATP is quickly consumed, and creatine can quickly re-synthesize ATP to supply energy.

Timely supplementation with creatine can effectively increase muscle strength, speed, and endurance. Improve physical fitness and training to prevent fatigue

It is especially necessary for vegetarians to supplement creatine.

Dosage: 500mg-5000mg

Creatine，Creatine Monohydrate, CMH，N-Amidinosarcosine  CreatineHydrate

Dandelion flavonoids 

In the 16th century, Germany used dandelion for "clear blood" and liver congestion. Until now, Switzerland, Poland, Hungary, and Russia still use it as a formal drug.

Role: liver and liver protection, choleretic agents, diuretics (will not filter out potassium) can cause blood pressure to drop, dehydration

Dandelion flavonoids can alleviate local pain and muscle pain

Omega3/6/9 fatty acid

Omega-3: Important omega-3 essential fatty acids including alpha-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), source linseed oil, perilla seed oil, hemp Kernel oil, peony seed oil, sea buckthorn oil, etc.

Omega-6: linoleic acid, arachidonic acid, etc., corn, soybeans, and other plants, pork, beef, lamb, Omega-6 unsaturated fatty acid content is quite a lot. Common borage oil

Omega-9: Oleic acid. Olive oil, linseed oil, evening primrose oil, and sorrel oil. High consumption of olive oil in Mediterranean countries is associated with a lower incidence of breast cancer and heart disease

Ginseng Extract, Ginkgo Biloba Extract

Ginseng root extract

Ginseng stem and leaf extract

Ginkgo Biloba Extract 24.0%Flavones 6.0% lactones

Glucosamine Chondroitin

Classic formula

Glucosamine + chondroitin sulfate + dimethyl sulfone

Glucosamine can help repair and maintain cartilage and stimulate the growth of chondrocytes

Chondroitin sulfate, derived from cartilage such as chicken, cow, pig, etc., can promote articular cartilage regeneration

Dimethyl sulfone: essential for the synthesis of collagen in the human body

Glutamine

It is the most abundant in human muscle tissue and therefore an essential supplement for bodybuilders. Everyone knows that protein helps growth, and glutamine is the most important part of the protein component that helps muscle growth.

Guarana Extract

It is rich in the Amazon River in northern Brazil and is the most well-known in Brazil. It has long been recorded in the rainforest medicinal plants.

Improve energy, lose weight, heart health

Alpha Lipoic Acid

Alpha-Lipoic Acid (ALA) is a mitochondrial compound that is highly involved in energy metabolism. 

ALA is a potent anti-oxidant compound. 

ALA also is an insulin-like substance

Features:

Strengthen liver function

Recover fatigue: increase energy metabolism

Improve dementia

Beauty and anti-aging

Medium Chain Triglycerides(MCT)

Medium chain fatty acids (MCFA) are composed of 6-12 carbon atoms and are relatively low in nature. They are mainly derived from palm oil, coconut oil, milk and so on. Coconut oil contains about 14%, palm oil contains about 7%, and milk and breast milk contain 1%-3%.

Improve the body's energy metabolism, promote fat decomposition, reduce the accumulation

Melatonine(MT)

Melatonin is a hormone in our body that tells you when to sleep

Brain Age

Other sports nutrition ingredients

Phosphate: Improves endurance and works with creatine

Pyruvate: This is a new supplement that is said to help “reduced fat without exercise”

Hedgehog saponin: promotes the production of testosterone. As testosterone promotes protein synthesis, the result is increased muscle growth and strength.

Barium sulfate: Vanadium sulfate is a good supplement that can make your muscles look and feel harder

Whey Protein: Whey is by far the best protein

White Willow Bark Extract: Natural Aspirin

S-Allyl-L-Cysteine(SAC) black garlic

(amy.cheng@cimasci.com)

What is aged black garlic?

Aged Black garlic is a pure natural health food adopting international leading special biological fermentation, screening high-quality garlic (Allium sativum) carefully, fermenting spontaneously after 60-90 days, soft and slippery, sweet and sour taste, black-jelly shape.

This form of garlic has some nutritional differences from traditional garlic and is widely used in high-end cooking applications. Due to the difficulty in producing it and the subsequent cost, it isn’t the most common ingredient to find on a spice shelf, but it does provide a number of unique health benefits. People consume aged black garlic by itself, grounding into a powder, infusing in oil, adding to vegetable dishes when mincing it into sauces or glazes. The flavor of aged black garlic is highly muted, in comparison to white garlic, so a rather large amount is needed to make an impact in most dishes. 

How to make aged black garlic extracts?

Fresh Garlic (Raw material)→Selecting→Peeling →Washing →Fermentation( Moisture, Temperature, and Humidity Control)→Drying→Grinding→Deioned Water  Extract→Centrifugal Separation→Refining→Vacuum Evaporation  Concentration →Precision Filtration→Spray Drying→Testing → Sieve → Packing →Sterilization → Product

 What specifications of aged black garlic extracts we have?

  CS-AGP-001     Aged Black Garlic Powder 10:1                     Odorless

  CS-AGP-002     Polyphenols≥3%                                             Odorless

  CS-AGP-003     S-Allyl-L-Cysteine（SAC）≥1%                  Odorless

  CS-AGP-004     Aged Black Garlic Extract Powder, Ajoene   Odorless

  CS-AGB-001       Aged Black Garlic Bulb

  CS-AGL-001     Aged Black Garlic Extract Liquid≥ 16.0 Brix

  CS-AGL-002     Aged Black Garlic Extract Liquid≥ 32.0 Brix

  OEM services: Aged Black Garlic capsules,soft gel.

Health benefits of aged black garlic extract The most notable health benefits of black garlic include its ability to protect against chronic disease, boost immunity, prevent cancer, regulate diabetes, and boost heart health, among others. Prevent Cancer The compound S-allyl cysteine(SAC) that forms when you blacken garlic has been shown to directly impact the formation of cancerous cells in your body, even more effectively than white garlic. This makes this specialty item even more important for people trying to boost their health through an exotic diet. Regulate Diabetes Aged black garlic is even more effective at regulating blood sugar levels. The active ingredients in this herb can help to slow the release of insulin into the body, which is important for diabetic patients and those who are at high risk of developing this condition. Improve Cardiovascular Health One of the amino acids found in our body, homocysteine, can actually damage blood vessels walls and compromise out cardiovascular health. Studies have found that aged black garlic is very good at reducing the levels of homocysteine in the blood, subsequently helping to protect our heart health. Boost Immunity Garlic is famous for its impact on the immune system, and the same thing is true of aged black garlic. It is known to boost the immune system’s strength and prevent a number of common bacterial and viral infections. It is particularly good for cleaning out the digestive tract and respiratory systems. Cimasci’s advantages: We produce this age black garlic from natural garlic according to GMP standard. As a large-scale manufacturer, we can supply high-quality products in large quantity. We could provide strong technical and academic support from our technical team consists of professors and PhDs.

Ajoene(in Garlic)

(amy.cheng@cimasci.com)

Garlic (Allium Satirum L.) is a perennial herb of the family Liliaceae. 

Garlic could be classified into purple garlic and white garlic, large garlic, and small garlic.

Garlic is rich in vitamins, amino acids, proteins, sugars, inorganic salts, and other nutrients. In addition, it contains selenium, barium and other trace elements, vitamin B1, vitamin A, vitamin C, SOD and other natural ingredients with obvious pharmacological activities.

The main active ingredients: Alliin, Allicin, research shows that these sulfur compounds have significant effects in reducing blood fat, improving immunity, bactericidal and antibacterial, anti-aging, promoting blood flow, anti-cancer and anti-cancer.

Black garlic has a soft, non-sticky taste, moderate sweetness, and sourness, no spicy or odor. Moreover, the content of sulfur compounds such as Ajoene and S-allyl-cysteine (SAC) is increased. Therefore, the physiological function of black garlic is greatly improved compared with fresh garlic.

Ajoene

Product name: Ajoene 

Other name:4,5,9-trithiadodeca-1,6,11-triene-9-oxide)

Molecular formula：C₉H₁₄OS₃

Molar mass:234.4g/mol

Two isomers:(E)-Ajoene;(Z)-Ajoene

Z-ajoene is more active than E-ajoene due to the presence of cis-carbon double bonds

The production process of ajoene in garlic:

Fresh garlic contains alliin (C₆H₁₁O₃NS) and alliinase, which are present in the cytoplasm and vacuole, respectively. When garlic is broken, alliin is converted to allyl sulfenic acid (C₃H₆OS) and dehydroalanine (C₃H₅O₂N) by the action of alliinase. Allyl sulfonic acid is produced allicin (ie, two Allyl thiosulfinate, C₆H₁₀OS₂)by disproportionation reaction. Allicin is extremely unstable and will be further decomposed into diallyl sulfide compounds (C₆H₁₀Sn, n=1~6), dithiane (C₆H₈S₂) and ajoene (C₉H₁₄OS₃, E, and Z). Therefore, it can be said that ajoene in garlic is the second degradation product of alliin.

Factors affecting the production of ajoene:

  

 Enzymatic hydrolysis time 5-30min

 pH5.0-6.5

 Temperature 4—35°C

 Solvent type Use:non-polar or weakly polar solvents (such as n-hexane, vegetable oil, etc.), polar solvents (such as methanol, ethanol, etc.)

The physiological function of ajoene

Ajoene is a highly biologically active sulfide that has the effects of preventing cardiovascular disease, anti-oxidation, anti-thrombosis, lowering blood pressure, reducing the incidence of Alzheimer's disease, resisting pathogenic bacteria, anti-virus, and improving immunity.

Ajoene has no spicy odor of garlic and is more biologically active than ether sulfur compounds and dithiene. Therefore, ajoene is easily accepted by people and has greater application potential in the production of medicines and health products.

Reference:The production process of ajoene in black garlic and its anti-hypertensive effect,by Guangyong Zhou,Prof.Yelian Miao

Weight Loss N-Oleoylethanolamide (OEA)

What's Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.

Chemistry Information:

Product name: Oleoylethanolamide, N-Oleoylethanolamide, OEA

Alias: N-(2-Hydroxyethyl)-9-Z-Octadecenamide,9-Octadecenamide, N-(2-Hydroxyethyl)oleamide，N-oleoyl ethanolamide, Oleoyl monoethanolamide,

CAS No: 111-58-0

Molecular Formula: C₂₀H₃₉NO₂

Molecular Weight:325.5

Assay: 85%-90%

Appearance: white to light yellow powder

The FAQ of Oleoylethanolamide (OEA)

Q: Why choose Oleoylethanolamide (OEA) for weight loss?

A: Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a molecule found in the intestines, reduce intake by a feeling of satiety after meals. So it’s very safe, with no side effect.

Q: What's the difference between OEA and traditional weight-reducing aid?

A: Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety following meals and doesn’t have any side effects.

Traditional weight-reducing usually contain Sibutramine. Sibutramine maybe leads to diabetes, high cholesterol, or high blood pressure if it is often used together with diet to treat obesity.

Q: What’s the advantage of Cima’s OEA Oleoylethanolamide?

A: Cima is the First & Unique manufacturer of OEA (Oleoylethanolamide)in China, regular stock available

Q: Do you have MOQ of Oleoylethanolamide (OEA)?

A: We don’t have MOQ, any quantity is workable, but the price is different. 

Oleoylethanolamide(OEA) in chronic lymphocytic leukemia

A role for Oleoylethanolamide(OEA) in chronic lymphocytic leukemia

As report showed from Masoodi M, Lee E...(Epub 2014 Jan 13.) found high amounts of OEA in the plasma of chronic lymphocytic leukemia (CLL) patients, and the magnitude of plasma OEA levels was related directly to the circulating leukemic cell number, based on a mass spectrometry lipidomics platform revealed.OEA from CLL cells was increased by URB-597, an inhibitor of fatty acid amide hydrolase (FAAH), and decreased by inflammatory mediators that downregulate expression of N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD). So they suggest OEA is a lipolytic factor produced by CLL cells to fuel their growth with a potential role in drug resistance and cancer cachexia.

Wuxi Cima Science could produce Oleoylethanolamide (OEA) 85%-90%fine powder. Please contact our sales team for quotes and samples with any interest.

What price of Pyrroloquinoline Quinone Disodium Salt (PQQ)?

Pyrroloquinoline quinone (PQQ) is redox cofactor. It is found in soil and foods such as kiwifruit, as well as human breast milk. Enzymes containing PQQ are called quinoproteins. Glucose dehydrogenase, one of the quinoproteins, is used as a glucose sensor. PQQ stimulates growth in bacteria.

--From Wikipedia

PQQ is an aromatic heterocyclic orthoquinone.

Chemical name: disodium 9-carboxy-4,5-dioxo-1H-pyrrolo[5,4-f]quinoline-2,7-dicarboxylate

Molecular formula: C₁₄H₄N₂Na₂O₈.

Molecular weight: 374.17

CAS number :122628-50-6

Appearance:reddish powder

Assay:98.0%min

Reference price:usd2400-usd2700/kg

PQQ was originally identified as a bacterial cofactor for primary alcohol dehydrogenases (Hauge, 1964; Anthony and Zatman, 1967; Salisbury et al., 1979; Duine and Jongejan, 1989). It has been reported to be produced by Gram-negative, methanol-utilizing bacteria, such as strains of the genera Hyphomicrobium and Methylobacterium where PQQ is biosynthesized from l-tyrosine and l-glutamic acid precursors (Houck et al., 1988; van Kleef and Duine, 1988; Urakami et al., 1992).

PQQ advised dosage

Dietary supplements containing PQQ are available in the USA and Canada for use by healthy adults at a maximum intake level of 50 mg/day and 20 mg/day (Health Canada, 2016), respectively.

--From EFSA Journals

WUXI CIMA SICENCE product details: 

Pyrroloquinoline Quinone Disodium Salt    in stocks