WUXI CIMA SCIENCE CO.,LTD

1/30/2019

Weight Loss N-Oleoylethanolamide (OEA)

What's Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.

Chemistry Information:

Product name: Oleoylethanolamide, N-Oleoylethanolamide, OEA

Alias: N-(2-Hydroxyethyl)-9-Z-Octadecenamide,9-Octadecenamide, N-(2-Hydroxyethyl)oleamide，N-oleoyl ethanolamide, Oleoyl monoethanolamide,

CAS No: 111-58-0

Molecular Formula: C₂₀H₃₉NO₂

Molecular Weight:325.5

Assay: 85%-90%

Appearance: white to light yellow powder

The FAQ of Oleoylethanolamide (OEA)

Q: Why choose Oleoylethanolamide (OEA) for weight loss?

A: Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a molecule found in the intestines, reduce intake by a feeling of satiety after meals. So it’s very safe, with no side effect.

Q: What's the difference between OEA and traditional weight-reducing aid?

A: Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety following meals and doesn’t have any side effects.

Traditional weight-reducing usually contain Sibutramine. Sibutramine maybe leads to diabetes, high cholesterol, or high blood pressure if it is often used together with diet to treat obesity.

Q: What’s the advantage of Cima’s OEA Oleoylethanolamide?

A: Cima is the First & Unique manufacturer of OEA (Oleoylethanolamide)in China, regular stock available

Q: Do you have MOQ of Oleoylethanolamide (OEA)?

A: We don’t have MOQ, any quantity is workable, but the price is different.

Oleoylethanolamide(OEA) in chronic lymphocytic leukemia

A role for Oleoylethanolamide(OEA) in chronic lymphocytic leukemia

As report showed from Masoodi M, Lee E...(Epub 2014 Jan 13.) found high amounts of OEA in the plasma of chronic lymphocytic leukemia (CLL) patients, and the magnitude of plasma OEA levels was related directly to the circulating leukemic cell number, based on a mass spectrometry lipidomics platform revealed.OEA from CLL cells was increased by URB-597, an inhibitor of fatty acid amide hydrolase (FAAH), and decreased by inflammatory mediators that downregulate expression of N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD). So they suggest OEA is a lipolytic factor produced by CLL cells to fuel their growth with a potential role in drug resistance and cancer cachexia.

Wuxi Cima Science could produce Oleoylethanolamide (OEA) 85%-90%fine powder. Please contact our sales team for quotes and samples with any interest.

What price of Pyrroloquinoline Quinone Disodium Salt (PQQ)?

Pyrroloquinoline quinone (PQQ) is redox cofactor. It is found in soil and foods such as kiwifruit, as well as human breast milk. Enzymes containing PQQ are called quinoproteins. Glucose dehydrogenase, one of the quinoproteins, is used as a glucose sensor. PQQ stimulates growth in bacteria.

--From Wikipedia

PQQ is an aromatic heterocyclic orthoquinone.

Chemical name: disodium 9-carboxy-4,5-dioxo-1H-pyrrolo[5,4-f]quinoline-2,7-dicarboxylate

Molecular formula: C₁₄H₄N₂Na₂O₈.

Molecular weight: 374.17

CAS number :122628-50-6

Appearance:reddish powder

Assay:98.0%min

Reference price:usd2400-usd2700/kg

PQQ was originally identified as a bacterial cofactor for primary alcohol dehydrogenases (Hauge, 1964; Anthony and Zatman, 1967; Salisbury et al., 1979; Duine and Jongejan, 1989). It has been reported to be produced by Gram-negative, methanol-utilizing bacteria, such as strains of the genera Hyphomicrobium and Methylobacterium where PQQ is biosynthesized from l-tyrosine and l-glutamic acid precursors (Houck et al., 1988; van Kleef and Duine, 1988; Urakami et al., 1992).

PQQ advised dosage

Dietary supplements containing PQQ are available in the USA and Canada for use by healthy adults at a maximum intake level of 50 mg/day and 20 mg/day (Health Canada, 2016), respectively.

--From EFSA Journals

WUXI CIMA SICENCE product details:

Pyrroloquinoline Quinone Disodium Salt in stocks

Red Yeast Rice(Monascus purpureus)

General Information:

Product Name: Functional Red Yeast Rice Extract, Red Yeast Rice Powder, Red Rice Powder

Botanic name: Monascus purpureus

Another name: red rice koji, akakoji, red fermented rice, red koji rice, Anka, orang-kak

Appearance: Reddish Brown to Dark Purple Powder

Active Ingredient: Monacolin K

Specifications: Monacolin K 0.4%,1.0%,1.5%,2.0%,3.0%,4.0%,5.0%

Test Method: HPLC

Source: Rice

Main Functions:

Comprehensive regulating blood lipids

Effective treatment of fatty liver, prevent excessive obesity

Auxiliary hypoglycemic

Inhibiting the tumor and treating prostatic hypertrophy

Promote bone formation and prevent osteoporosis

Red Yeast Rice Extract Application:

In ancient times, Red Yeast Rice Extract is not only used in culinary but also used in Chinese herbology and traditional Chinese medicine.

Nowadays, Red Yeast Rice Extract is widely used in dietary supplement and healthcare. It is taken to invigorate the body, aid in digestion, and revitalize the blood.

WUXI CIMA SCIENCE offer:

1. Top quality monacolin K

2. Citrinin free.

3. Irradiation Free.

4. GMO-Free.

5. Meet EU standards

6. OEM service.

Factory producing process:

Oleoylethanolamide(OEA)

CimaSci promotes health and well-being through the discovery and development of nutraceutical ingredient which can be integrated into dietary supplements, nutritional production, and medicine.

Oleoylethanolamide (OEA) is an endocannabinoid analog that belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.

Chemical Profile

CAS No: 111-58-0

Molecular Weight: 325.5

Molecular Formula: C₂₀H₃₉NO₂

How does OEA Work?

OEA works to activate something called PPAR and simultaneously ramps up fat-burning and decreases fat storage. When you eat, OEA levels increase and your appetite decreases when the sensory nerves that link to your brain tell it that you're full.

Oleoylethanolamide is a potent endogenous ligand for Peroxisome proliferator-activated receptors α(PPARα), nuclear receptors involved in the transcriptional regulation of lipid metabolism, inflammation, and neuroplasticity. Further study demonstrated that treatment with OEA markedly increased the expressions of brain-derived neurotrophic factor and PPARα. It has been confirmed that OA treatment can exert functional recovery of cognitive impairments and neuroprotective effects against cerebral ischemic insult in rats via triggering of neurogenesis in the hippocampus, which supports the therapeutic use of OEA for cerebral ischemia.

Pharmacological augmentation of endocannabinoid signaling can produce both antidepressant and anxiolytic behavioral Anandamide represents the most studied compound mainly for its ability to act as an endogenous ligand for cannabinoid receptor type 1 (CB1). A large body of evidence has clearly demonstrated that the stimulation of this receptor exerts powerful effects on energy balance, increasing appetitive drive and promoting adiposity. OEA exerts opposite effects on feeding regulation and lipid metabolism. OEA suppresses appetite by stimulating satiety and that its profile of action might be predictive of safer effects in humans as a novel antiobesity treatment.

Functions

OEA--Promote neurogenesis and neuroplasticity after focal cerebral
OEA--Anti-depressant
OEA--Anti-obesity
OEA--Anti-atherosclerosis
OEA--Decrease appetite

Safety

OEA original material is natural palm oil
OEA suppresses appetite by stimulating satiety and shows safer effects in humans as a novel antiobesity treatment.
OEA is different with the endocannabinoid, can modulate food intake control through interaction with PPAR-alpha

what price of Alpha-GPC?

Alpha-GPC

GPC is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources.

Chemical Profile

CAS No.: 28319-77-9
Molecular Weight: 257.22 Molecular Formula: C₈H₂₀NO₆P

Benefits

Cognitive Improve
Improve Growth Hormone
Power Output
Symptoms of Alzheimer's
Improve balance and coordination
Enhance learning

Advance of cima

Cima Science Co., Ltd as an innovator in the chemical, biotechnological and phytochemical fields, has almost 10 years in dealing with this product.

We have complete product specifications in bulk :

1) 99% powder reference price:usd220/kg
2) 85% liquid reference price:usd185/kg

3) 50% granular powder, no hygroscopy reference price:usd120/kg
4) 50% powder, water soluble. reference price:usd100/kg

We have comprehensive files system :

Process validation; Cleaning validation; Test method validation; Stability validation...

Our GPC is total synthesis :

Compared with partial synthesis, ours has higher purity; lower endotoxin; lower production cost.

Only producer for 50% granular powder of no hygroscopy!

where you buy Palmitoylethanolamide?

Cimasci. is a professional manufacturer in offering Chemical nutritions and herb extracts:

Palmitoylethanolamide (Cas No.544-31-0) we offer 98%fine powder, functions at Anti-inflammatory &pain reliever.

PEA 98%powder;

PEA Micronized powder;

PEA capsules(400mg).

If interest, please contact us!

Cholesterol-Lowering Supplement -Functional Red Yeast Rice Extract Monascus purpureus

What is Red Yeast Rice?

Red yeast rice, also called Red rice, Red Koji Rice, is made by culturing rice with various strains of the yeast Monascus purpureus. Some preparations of red yeast rice are used in food products in Chinese cuisine, including Peking duck. Others have been made into dietary supplements to lower blood levels of cholesterol and related lipids.

Functional red yeast rice products contain substances called monacolin K, which is currently the most effective naturally occurring statin. It is able, like most statins, to lower blood cholesterol levels by reducing the production of cholesterol by the liver.

Product Information:

Product Name: Functional Red Yeast Rice Extract, Red Yeast Rice Powder, Red Rice Powder

Appearance: Reddish Brown to Dark Purple Powder

Active Ingredient: Monacolin K

Specifications: Monacolin K 0.4% -5%

Test Method: HPLC

Source: Rice

Is Red Yeast Rice Extract a Drug or a Nutritional Supplement?

Confusingly, the answer is both. One of the most important ingredients in Red Yeast Rice Extracts is monacolin K, which can help to lower cholesterol.

Health Benefits of Functional Red Yeast Rice Extracts

1. Help for High Cholesterol

Red yeast rice supplements are most often taken to naturally lower hyperlipidemia or high cholesterol. The red yeast (Monascus purpureus) used to make red yeast rice has been shown to stop the action of an enzyme in the human body that helps form cholesterol. There have been a lot of studies showing the positive effects of red yeast rice extract on cholesterol.

2. Help for osteoporosis syndrome

The scientist found an element called ergosterol in red yeast rice extracts, which is the precursor of fat-soluble vitamin D2, and then transformed into vitamin D2 under UV radiation. As we all know vitamin D2 can promote absorption of calcium and phosphorus.

3. Help in lowering blood pressure

It’s researched that the element GABA exists in the fermentation broth of red yeast rice, and can help to lower blood pressure.

4. Anti-Cancer and Protect the kidney

Monacolin K can reduce the mitotic index of cancer cell and activity of Na⁺-K⁺-ATP enzyme, and inhibit the growth of cancer cell.

Pharmacological studies have shown that Monacolin K has a significant inhibition of mesangial cell proliferation and extracellular matrix secretion. So it has the function of protecting the kidneys.

Safety of CIMA’s Red Yeast Rice Extracts

- High proportion of acid form Monacolin k, which has less side effect than lactone form. Acid form VS lactone form is 80:20,

- Citrinin free

- Irradiation Free

- 100% Solid Fermentation, which ensure less bacterial contamination.

Applications of Functional Red Yeast Rice Extracts

- As the additive of dietary supplement and healthcare food to lower cholesterol, also some supplement products also use it to to combine with other ingredients, for example, bone-protecting products combining red yeast rice extracts with organic acid calcium; Menopausal Syndrome treating products combining red yeast rice extracts with plant hormone.

- Medical uses.

HUPERZIA SERRATE EXTRACT HUPERZINE A1％--99％ CAS NO.: 102518-79-6

HUPERZIA SERRATE EXTRACT

BOTANIC NAME: HUPERZIA SERRATA(THUMB.)TREV

NATURAL HUPERZINE A 1%--99%POWDER

CAS NO.: 102518-79-6

CIMASCI PROVIDE HUPERZINE A 1% POWDER

HUPERZINE A BENEFITS:

Enhance cognition, improve memory;

Contribute to restoring short-term memory damage, slow brain aging;

Improve age-related memory loss and Alzheimer's disease

HUPERZINE A SIDE EFFECTS &SAFETY

Huperzine A is POSSIBLY SAFE when taken by mouth for a short period of time (less than 3 months). It can cause some side effects including nausea, diarrhea, vomiting, sweating, blurred vision, slurred speech, restlessness, loss of appetite, contraction, and twitching of muscle fibers, cramping, increased saliva and urine, inability to control urination, high blood pressure, and slowed heart rate.

--from www.webmd.com