1/30/2019

S-Allyl-L-Cysteine(SAC) black garlic

(amy.cheng@cimasci.com)


What is aged black garlic?

Aged Black garlic is a pure natural health food adopting international leading special biological fermentation, screening high-quality garlic (Allium sativum) carefully, fermenting spontaneously after 60-90 days, soft and slippery, sweet and sour taste, black-jelly shape.

This form of garlic has some nutritional differences from traditional garlic and is widely used in high-end cooking applications. Due to the difficulty in producing it and the subsequent cost, it isn’t the most common ingredient to find on a spice shelf, but it does provide a number of unique health benefits. People consume aged black garlic by itself, grounding into a powder, infusing in oil, adding to vegetable dishes when mincing it into sauces or glazes. The flavor of aged black garlic is highly muted, in comparison to white garlic, so a rather large amount is needed to make an impact in most dishes. 

How to make aged black garlic extracts?



Fresh Garlic (Raw material)→Selecting→Peeling →Washing →Fermentation( Moisture, Temperature, and Humidity Control)→Drying→Grinding→Deioned Water  Extract→Centrifugal Separation→Refining→Vacuum Evaporation  Concentration →Precision Filtration→Spray Drying→Testing → Sieve → Packing →Sterilization → Product


 What specifications of aged black garlic extracts we have?


  CS-AGP-001     Aged Black Garlic Powder 10:1                     Odorless
  CS-AGP-002     Polyphenols≥3%                                             Odorless
  CS-AGP-003     S-Allyl-L-Cysteine(SAC)≥1%                  Odorless
  CS-AGP-004     Aged Black Garlic Extract Powder, Ajoene   Odorless
  CS-AGB-001       Aged Black Garlic Bulb
  CS-AGL-001     Aged Black Garlic Extract Liquid≥ 16.0 Brix
  CS-AGL-002     Aged Black Garlic Extract Liquid≥ 32.0 Brix

  OEM services: Aged Black Garlic capsules,soft gel.


Health benefits of aged black garlic extract

The most notable health benefits of black garlic include its ability to protect against chronic disease, boost immunity, prevent cancer, regulate diabetes, and boost heart health, among others.

Prevent Cancer
The compound S-allyl cysteine(SAC) that forms when you blacken garlic has been shown to directly impact the formation of cancerous cells in your body, even more effectively than white garlic. This makes this specialty item even more important for people trying to boost their health through an exotic diet.

Regulate Diabetes
Aged black garlic is even more effective at regulating blood sugar levels. The active ingredients in this herb can help to slow the release of insulin into the body, which is important for diabetic patients and those who are at high risk of developing this condition.

Improve Cardiovascular Health
One of the amino acids found in our body, homocysteine, can actually damage blood vessels walls and compromise out cardiovascular health. Studies have found that aged black garlic is very good at reducing the levels of homocysteine in the blood, subsequently helping to protect our heart health.

Boost Immunity
Garlic is famous for its impact on the immune system, and the same thing is true of aged black garlic. It is known to boost the immune system’s strength and prevent a number of common bacterial and viral infections. It is particularly good for cleaning out the digestive tract and respiratory systems.



Cimascis advantages:

We produce this age black garlic from natural garlic according to GMP standard.
As a large-scale manufacturer, we can supply high-quality products in large quantity.
We could provide strong technical and academic support from our technical team consists of professors and PhDs.



Ajoene(in Garlic)

(amy.cheng@cimasci.com)




Garlic (Allium Satirum L.) is a perennial herb of the family Liliaceae. 
Garlic could be classified into purple garlic and white garlic, large garlic, and small garlic.
Garlic is rich in vitamins, amino acids, proteins, sugars, inorganic salts, and other nutrients. In addition, it contains selenium, barium and other trace elements, vitamin B1, vitamin A, vitamin C, SOD and other natural ingredients with obvious pharmacological activities.

The main active ingredients: Alliin, Allicin, research shows that these sulfur compounds have significant effects in reducing blood fat, improving immunity, bactericidal and antibacterial, anti-aging, promoting blood flow, anti-cancer and anti-cancer.

Black garlic has a soft, non-sticky taste, moderate sweetness, and sourness, no spicy or odor. Moreover, the content of sulfur compounds such as Ajoene and S-allyl-cysteine (SAC) is increased. Therefore, the physiological function of black garlic is greatly improved compared with fresh garlic.

Ajoene



Product name: Ajoene 
Other name:4,5,9-trithiadodeca-1,6,11-triene-9-oxide)
Molecular formula:C9H14OS3
Molar mass:234.4g/mol
Two isomers:(E)-Ajoene;(Z)-Ajoene
Z-ajoene is more active than E-ajoene due to the presence of cis-carbon double bonds



The production process of ajoene in garlic:

Fresh garlic contains alliin (C6H11O3NS) and alliinase, which are present in the cytoplasm and vacuole, respectively. When garlic is broken, alliin is converted to allyl sulfenic acid (C3H6OS) and dehydroalanine (C3H5O2N) by the action of alliinase. Allyl sulfonic acid is produced allicin (ie, two Allyl thiosulfinate, C6H10OS2)by disproportionation reaction. Allicin is extremely unstable and will be further decomposed into diallyl sulfide compounds (C6H10Sn, n=1~6), dithiane (C6H8S2) and ajoene (C9H14OS3, E, and Z). Therefore, it can be said that ajoene in garlic is the second degradation product of alliin.



Factors affecting the production of ajoene:
  
 Enzymatic hydrolysis time 5-30min
 pH5.0-6.5
 Temperature 4—35°C
 Solvent type Use:non-polar or weakly polar solvents (such as n-hexane, vegetable oil, etc.), polar solvents (such as methanol, ethanol, etc.)

The physiological function of ajoene

Ajoene is a highly biologically active sulfide that has the effects of preventing cardiovascular disease, anti-oxidation, anti-thrombosis, lowering blood pressure, reducing the incidence of Alzheimer's disease, resisting pathogenic bacteria, anti-virus, and improving immunity.

Ajoene has no spicy odor of garlic and is more biologically active than ether sulfur compounds and dithiene. Therefore, ajoene is easily accepted by people and has greater application potential in the production of medicines and health products.


Reference:The production process of ajoene in black garlic and its anti-hypertensive effect,by Guangyong Zhou,Prof.Yelian Miao

Weight Loss N-Oleoylethanolamide (OEA)


What's Oleoylethanolamide (OEA)?
Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.


Chemistry Information:
Product name: Oleoylethanolamide, N-Oleoylethanolamide, OEA
Alias: N-(2-Hydroxyethyl)-9-Z-Octadecenamide,9-Octadecenamide, N-(2-Hydroxyethyl)oleamide,N-oleoyl ethanolamide, Oleoyl monoethanolamide,
CAS No: 111-58-0
Molecular Formula: C20H39NO2
Molecular Weight:325.5
Assay: 85%-90%
Appearance: white to light yellow powder



The FAQ of Oleoylethanolamide (OEA)

Q: Why choose Oleoylethanolamide (OEA) for weight loss?
A: Oleoylethanolamide (OEA) or N-Oleoylethanolamide (OEA) is a molecule found in the intestines, reduce intake by a feeling of satiety after meals. So it’s very safe, with no side effect.

Q: What's the difference between OEA and traditional weight-reducing aid?
A: Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety following meals and doesn’t have any side effects.
Traditional weight-reducing usually contain Sibutramine. Sibutramine maybe leads to diabetes, high cholesterol, or high blood pressure if it is often used together with diet to treat obesity.

Q: What’s the advantage of Cimas OEA Oleoylethanolamide?
A: Cima is the First & Unique manufacturer of OEA (Oleoylethanolamide)in China, regular stock available

Q: Do you have MOQ of Oleoylethanolamide (OEA)?
A: We don’t have MOQ, any quantity is workable, but the price is different. 

Oleoylethanolamide(OEA) in chronic lymphocytic leukemia

A role for Oleoylethanolamide(OEA) in chronic lymphocytic leukemia
As report showed from Masoodi M, Lee E...(Epub 2014 Jan 13.) found high amounts of OEA in the plasma of chronic lymphocytic leukemia (CLL) patients, and the magnitude of plasma OEA levels was related directly to the circulating leukemic cell number, based on a mass spectrometry lipidomics platform revealed.OEA from CLL cells was increased by URB-597, an inhibitor of fatty acid amide hydrolase (FAAH), and decreased by inflammatory mediators that downregulate expression of N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD). So they suggest OEA is a lipolytic factor produced by CLL cells to fuel their growth with a potential role in drug resistance and cancer cachexia.

Wuxi Cima Science could produce Oleoylethanolamide (OEA) 85%-90%fine powder. Please contact our sales team for quotes and samples with any interest.




What price of Pyrroloquinoline Quinone Disodium Salt (PQQ)?


Pyrroloquinoline quinone (PQQ) is redox cofactor. It is found in soil and foods such as kiwifruit, as well as human breast milk. Enzymes containing PQQ are called quinoproteins. Glucose dehydrogenase, one of the quinoproteins, is used as a glucose sensor. PQQ stimulates growth in bacteria.
--From Wikipedia

PQQ is an aromatic heterocyclic orthoquinone.
Chemical name: disodium 9-carboxy-4,5-dioxo-1H-pyrrolo[5,4-f]quinoline-2,7-dicarboxylate
Molecular formula: C14H4N2Na2O8.
Molecular weight: 374.17
CAS number :122628-50-6
Appearance:reddish powder
Assay:98.0%min
Reference price:usd2400-usd2700/kg
















PQQ was originally identified as a bacterial cofactor for primary alcohol dehydrogenases (Hauge, 1964; Anthony and Zatman, 1967; Salisbury et al., 1979; Duine and Jongejan, 1989). It has been reported to be produced by Gram-negative, methanol-utilizing bacteria, such as strains of the genera Hyphomicrobium and Methylobacterium where PQQ is biosynthesized from l-tyrosine and l-glutamic acid precursors (Houck et al., 1988; van Kleef and Duine, 1988; Urakami et al., 1992).

PQQ advised dosage
Dietary supplements containing PQQ are available in the USA and Canada for use by healthy adults at a maximum intake level of 50 mg/day and 20 mg/day (Health Canada, 2016), respectively.

--From EFSA Journals


WUXI CIMA SICENCE product details: 

Pyrroloquinoline Quinone Disodium Salt    in stocks







Red Yeast Rice(Monascus purpureus)

General Information:

Product Name: Functional Red Yeast Rice Extract, Red Yeast Rice Powder, Red Rice Powder
Botanic name: Monascus purpureus
Another name: red rice koji, akakoji, red fermented rice, red koji rice, Anka, orang-kak
Appearance: Reddish Brown to Dark Purple Powder
Active Ingredient: Monacolin K
Specifications: Monacolin K 0.4%,1.0%,1.5%,2.0%,3.0%,4.0%,5.0%
Test Method: HPLC
Source: Rice

Main Functions:
Comprehensive regulating blood lipids
Effective treatment of fatty liver, prevent excessive obesity
Auxiliary hypoglycemic
Inhibiting the tumor and treating prostatic hypertrophy
Promote bone formation and prevent osteoporosis

Red Yeast Rice Extract Application:
In ancient times, Red Yeast Rice Extract is not only used in culinary but also used in Chinese herbology and traditional Chinese medicine.
Nowadays, Red Yeast Rice Extract is widely used in dietary supplement and healthcare. It is taken to invigorate the body, aid in digestion, and revitalize the blood.

WUXI CIMA SCIENCE offer:
1. Top quality monacolin K
2. Citrinin free.
3. Irradiation Free.
4. GMO-Free.
5. Meet EU standards
6. OEM service.

Factory producing process:









Oleoylethanolamide(OEA)



CimaSci promotes health and well-being through the discovery and development of nutraceutical ingredient which can be integrated into dietary supplements, nutritional production, and medicine.

Oleoylethanolamide (OEA) is an endocannabinoid analog that belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.


Chemical Profile
CAS No: 111-58-0
Molecular Weight: 325.5 
Molecular Formula: C20H39NO2








How does OEA Work?

OEA works to activate something called PPAR and simultaneously ramps up fat-burning and decreases fat storage. When you eat, OEA levels increase and your appetite decreases when the sensory nerves that link to your brain tell it that you're full. 

Oleoylethanolamide is a potent endogenous ligand for Peroxisome proliferator-activated receptors α(PPARα), nuclear receptors involved in the transcriptional regulation of lipid metabolism, inflammation, and neuroplasticity. Further study demonstrated that treatment with OEA markedly increased the expressions of brain-derived neurotrophic factor and PPARα. It has been confirmed that OA treatment can exert functional recovery of cognitive impairments and neuroprotective effects against cerebral ischemic insult in rats via triggering of neurogenesis in the hippocampus, which supports the therapeutic use of OEA for cerebral ischemia.

Pharmacological augmentation of endocannabinoid signaling can produce both antidepressant and anxiolytic behavioral Anandamide represents the most studied compound mainly for its ability to act as an endogenous ligand for cannabinoid receptor type 1 (CB1). A large body of evidence has clearly demonstrated that the stimulation of this receptor exerts powerful effects on energy balance, increasing appetitive drive and promoting adiposity. OEA exerts opposite effects on feeding regulation and lipid metabolism. OEA suppresses appetite by stimulating satiety and that its profile of action might be predictive of safer effects in humans as a novel antiobesity treatment.

Functions
  • OEA--Promote neurogenesis and neuroplasticity after focal cerebral
  • OEA--Anti-depressant
  • OEA--Anti-obesity
  • OEA--Anti-atherosclerosis
  • OEA--Decrease appetite 

Safety
  • OEA original material is natural palm oil
  • OEA  suppresses appetite by stimulating satiety and shows safer effects in humans as a novel antiobesity treatment.
  • OEA  is different with the endocannabinoid, can modulate food intake control through interaction with PPAR-alpha



what price of Alpha-GPC?




Alpha-GPC

GPC is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources. 


Chemical Profile


CAS No.: 28319-77-9

Molecular Weight: 257.22 Molecular Formula: C8H20NO6P

Benefits
  • Cognitive Improve
  • Improve Growth Hormone
  • Power Output 
  • Symptoms of Alzheimer's
  • Improve balance and coordination
  • Enhance learning


Advance of cima

Cima Science Co., Ltd as an innovator in the chemical, biotechnological and phytochemical fields, has almost 10 years in dealing with this product.

We have complete product specifications in bulk :
1)  99% powder          reference price:usd220/kg
 2) 85% liquid           reference price:usd185/kg
3)  50% granular powder, no hygroscopy       reference price:usd120/kg 
4) 50% powder, water soluble.                 reference price:usd100/kg

We have comprehensive files system : 
Process validation; Cleaning validation; Test method validation; Stability validation...

Our GPC is total synthesis :
Compared with partial synthesis, ours has higher purity; lower endotoxin; lower production cost.

Only producer for 50% granular powder of no hygroscopy!